Analisys of Cortical Excitability and Motor Function of Post Stroke Patients

NCT03627364 | Completed

• 1 other identifier: motor function_stroke
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 2

Brief Summary

Healthy individuals, after reading and signing the free and informed consent will be submitted to a single session to obtain the normal neurophysiological measures and thus compare with those obtained in individuals with PD. Healthy and post stroke patients will be submitted to a neurophysiological evaluation through transcranial magnetic stimulation (TMS) and electroencephalography (EEG). The post stroke patients will also performed the evaluation trought the fugl meyer scale.

Conditions

Stroke; Motor Function; Cortical Excitability

Outcome Measures

Primary Outcomes (1)

• sensory-motor recovery level

  Fugl Meyer assesment of paretic upper limb motor function is used to measure motor control recovery. It is a 226 point scoring system that includes the following sessions: range of motion, pain, sensation,motor function of upper and lower limbs, balance, coordination and velocity. We will aplly only two sessions: upper limb motor function and coordination/velocity, these sessions totalize 66 points

  baseline

Secondary Outcomes (2)

• Cortical excitabilit level

  baseline

• level of cortical electrical activity

  baseline

Study Arms (2)

Post stroke patients

will be submitted to a single session to obtain the normal neurophysiological and behavioral endpoints and thus compare with those obtained in healthy individuals.

Control group

will be submitted to a single session to obtain the normal neurophysiological and behavioral endpoints and thus compare with those obtained in post stroke patients.

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The population study was composite for patients post-stroke with auditory major that 3 months and found in the eligibility criteria. In addition, it will rely on babies with health or neurological disorders.

You may qualify if:

• Post stroke patients
• Primary or recurrent, ischemic or hemorrhagic stroke, confirmed by computed tomography or magnetic resonance imaging
• Chronic Stroke (\> 3 months)
• Sensorimotor sequelae in an upper limb due to stroke
• Score ≥ 18 at Folstein Mini Mental State Examination Healthy Subjects
• Ages: 40 years or greater
• Gender: Both
• Subjects who do not have self-report of neurological or articular disorder

You may not qualify if:

• Post stroke patients
• Prior neurological diseases
• Multiple brain lesions
• Metal implant in the skull and face
• Pacemaker
• History of seizures
• Epilepsy
• Pregnancy
• Hemodynamic instability
• Traumatic orthopedic injuries of upper limb that compromise the function
• Altered medication for less than 3 months or who underwent botulinum toxin for less than 6 months
• Performing physical therapy elsewhere during the period of intervention Healthy Subjects
• Pregnant women;
• Pacemaker;
• History of seizures;

Sponsors & Collaborators

• Universidade Federal de Pernambuco: lead

Study Sites (2)

Applied Neuroscience Laboratory, Universidade Federal de Pernambuco

Recife, Pernambuco, 50670-900, Brazil

Location

Applied Neuroscience Laboratory

Recife, Pernambuco, 50740-560, Brazil

Location

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: August 8, 2018
• First Posted: August 13, 2018
• Study Start: August 15, 2018
• Primary Completion: December 20, 2018
• Study Completion: March 3, 2019
• Last Updated: May 6, 2020

Record last verified: 2020-05

Data Sharing

• IPD Sharing: Will not share

Locations

BR (2)