The Effect of Dexmedetomidine for Emergence Cough
1 other identifier
interventional
48
1 country
1
Brief Summary
Dexmedetomidine or remifentanil are effective in attenuating cough during peri-extubation period after general anesthesia. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Aug 2018
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 6, 2018
CompletedFirst Posted
Study publicly available on registry
August 9, 2018
CompletedStudy Start
First participant enrolled
August 16, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 22, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
March 27, 2019
CompletedJanuary 9, 2020
January 1, 2020
7 months
August 6, 2018
January 6, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of cough
Number of cough or a strong and sudden contraction of the abdomen during periextubation periextubation periods
from end of surgery to 5 min after tracheal extubation]
Study Arms (2)
Dexmedetomidine
EXPERIMENTALDexmedetomidine was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period
Remifentanil
ACTIVE COMPARATORNormal saline was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period
Interventions
Dexmedetomidine 0.5mcg/kg was infused over 10 min before end of the surgery
Remifentanil was maintained at predetermined effect-site concentration during the periextubation period (initial concentration: 2.0 ng/ml)
Normal saline was infused over 10 min before end of the surgery
Eligibility Criteria
You may qualify if:
- ASA physical status I or II undergoing endoscopic sinus surgery or septoplasty under general anesthesia
You may not qualify if:
- predicted difficult airway
- body mass index \> 35 kg/m2,
- recent upper respiratory infection
- asthma
- current smoker
- patients using angiotensin converting enzyme-inhibitors
- uncontrolled hypertension
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ajou University Hospital
Suwon, Gyeongki-do, 443-721, South Korea
Related Publications (1)
Kim HY, Kwak HJ, Lee D, Lee JH, Min SK, Kim JY. Comparison of remifentanil concentrations with and without dexmedetomidine for the prevention of emergence cough after nasal surgery: a randomized double-blinded trial. BMC Anesthesiol. 2021 May 4;21(1):136. doi: 10.1186/s12871-021-01358-x.
PMID: 33941098DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jong Yeop Kim
Ajou University Hospital, Suwon, Gyeongki-do, Korea
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- CARE PROVIDER, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
August 6, 2018
First Posted
August 9, 2018
Study Start
August 16, 2018
Primary Completion
March 22, 2019
Study Completion
March 27, 2019
Last Updated
January 9, 2020
Record last verified: 2020-01