Endometrioma Per se Versus Treatment Related Reduction in Ovarian Reserve (ERROR-2 Trial)
ERROR2
1 other identifier
observational
250
1 country
1
Brief Summary
The present multi-center study aimed to evaluate whether endometrioma-associated decline in ovarian reserve is progressive in the absence of an intervention and is greater in magnitude than the natural decline over time. Also the affect of endometrioma treatment modalities like surgery or medical on the ovarian reserve over time.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2019
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 23, 2018
CompletedFirst Posted
Study publicly available on registry
August 8, 2018
CompletedStudy Start
First participant enrolled
March 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2020
CompletedOctober 10, 2019
October 1, 2019
1.5 years
July 23, 2018
October 8, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
AMH
Change from baseline Anti müllerian hormone levels at 6 months
6 months
Secondary Outcomes (1)
AFC
6 months
Study Arms (5)
Group 1
Patients with endometrioma who had at least one endometrioma \>3 cm and who will not need hormonal or surgical treatment at the time of diagnosis and who will be expectantly managed
Group 2
Patients with endometrioma who had at least one endometrioma \>3 cm and who will be treated with OCP during the study period
Group 3
Patients with endometrioma who had at least one endometrioma \>3 cm and who will be treated with oral progesterone during the study period
Group 4
Patients with endometrioma who had at least one endometrioma \>3 cm and who will be treated with surgery short after recruitment
Group 5
The control group, who do not have endometrioma and any gynecological disorder
Interventions
ovarian endometrioma cyst excision
Eligibility Criteria
Patients with endometriomas
You may qualify if:
- Women between 18 and 40 years of age
- Who had at least one endometrioma \>3 cm
You may not qualify if:
- İrregular periods
- Polycystic ovarian syndrome
- Pregnant patients
- Patients unable to give informed consent • Using medication which could affect ovarian function during six months before recruitment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Uludag University Scholl of medicine
Bursa, Turkey/bursa, Turkey (Türkiye)
Related Publications (1)
Aslan K, Kasapoglu I, Kosan B, Gurbuz TB, Muzii L, Uncu G. Impact of endometrioma management strategies on ovarian reserve over the follow-up period, a prospective longitudinal study. Front Endocrinol (Lausanne). 2025 Sep 11;16:1631108. doi: 10.3389/fendo.2025.1631108. eCollection 2025.
PMID: 41019321DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator ; Prof. Dr. Gürkan Uncu
Study Record Dates
First Submitted
July 23, 2018
First Posted
August 8, 2018
Study Start
March 1, 2019
Primary Completion
September 1, 2020
Study Completion
September 1, 2020
Last Updated
October 10, 2019
Record last verified: 2019-10