NCT03618303|Completed
PET-MR Imaging of Coronary Atherothrombosis
Combined Positron Emission Tomography and Magnetic Resonance Imaging of Coronary Atherothrombosis
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Combined Positron Emission Tomography and Magnetic Resonance Imaging of Coronary Atherothrombosis
Sponsor study identifier
interventional
9
1 country
1
Study Start
July 16, 2018
Actual (reported)Primary Completion
March 24, 2020
Actual (reported)Study Completion
March 24, 2020
Actual (reported)Heart attacks remain a common cause of death throughout the world. The most common initiating event is the formation of a blood clot within the coronary arteries occluding blood supply to the heart. However, we know that thrombus often occurs within the coronary arteries without causing any symptoms, and may be found in patients with stable angina. We wish to investigate whether blood clots within the coronary arteries can be detected in patients who have had a heart attack and in patients with stable angina using combined positron emission tomography and magnetic resonance (PET-MR) imaging. If possible, this may provide a safe and noninvasive means of identifying patients at higher risk of heart attacks. The study will be conducted in Edinburgh Heart Centre and a total of 40 participants will be recruited from the cardiology wards, outpatient clinics and day case unit. Participants will be asked to undergo a single PET-MRI scan in addition to invasive angiography as part of standard care (non-research procedure). During the invasive angiogram procedure, an additional imaging test may be performed called Optical Coherence Tomography to provide images from within the heart blood vessels.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 24, 2020
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 16, 2018
Actual (reported)July 31, 2018
Actual (reported)August 7, 2018
Actual (reported)March 24, 2020
Actual (reported)March 24, 2020
Actual (reported)Plaque-to-myocardial ratio of culprit plaques on T1-weighted imaging
The identification of high risk plaques on T1-weighted MRI to determine whether coronary atherothrombosis can accurately be detected using non-invasive PET-MR imaging.
Baseline
The correlation between high risk plaques on PET-MR and culprit plaques on invasive angiography in patients with coronary artery disease.
Baseline
The correlation between coronary plaque thrombosis (MRI), high-risk plaque (PET) and the presence of myocardial infarction on MRI (late enhancement).
Baseline
All patients will undergo the same intervention of having a PET-MRI scan and optical coherence tomography.
Patients will undergo combined Positron Emission Tomography and Magnetic Resonance Imaging prior to a planned invasive angiogram (performed as standard of care). During the angiogram procedure, an additional imaging test (optical coherence tomography) will be performed.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Queen's Medical Research Institute
Edinburgh, Scotland, EH16 4SB, United Kingdom
Xie Y, Kim YJ, Pang J, Kim JS, Yang Q, Wei J, Nguyen CT, Deng Z, Choi BW, Fan Z, Bairey Merz CN, Shah PK, Berman DS, Chang HJ, Li D. Coronary Atherosclerosis T1-Weighed Characterization With Integrated Anatomical Reference: Comparison With High-Risk Plaque Features Detected by Invasive Coronary Imaging. JACC Cardiovasc Imaging. 2017 Jun;10(6):637-648. doi: 10.1016/j.jcmg.2016.06.014. Epub 2016 Oct 12.
Noguchi T, Kawasaki T, Tanaka A, Yasuda S, Goto Y, Ishihara M, Nishimura K, Miyamoto Y, Node K, Koga N. High-intensity signals in coronary plaques on noncontrast T1-weighted magnetic resonance imaging as a novel determinant of coronary events. J Am Coll Cardiol. 2014 Mar 18;63(10):989-99. doi: 10.1016/j.jacc.2013.11.034. Epub 2013 Dec 15.
Mhairi K Doris, MBChB
University of Edinburgh
David E Newby, PhD DM DSc
University of Edinburgh
9 participants (actual enrollment reported by the registry).
First Submitted
July 31, 2018
First Posted
August 7, 2018
Study Start
July 16, 2018
Actual (reported)Primary Completion
Stress Reduction Intervention for Women With Ischemic Heart Disease
Contact the study team to confirm eligibility.
Joshi NV, Vesey AT, Williams MC, Shah AS, Calvert PA, Craighead FH, Yeoh SE, Wallace W, Salter D, Fletcher AM, van Beek EJ, Flapan AD, Uren NG, Behan MW, Cruden NL, Mills NL, Fox KA, Rudd JH, Dweck MR, Newby DE. 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial. Lancet. 2014 Feb 22;383(9918):705-13. doi: 10.1016/S0140-6736(13)61754-7. Epub 2013 Nov 11.
Matsumoto K, Ehara S, Hasegawa T, Sakaguchi M, Otsuka K, Yoshikawa J, Shimada K. Localization of Coronary High-Intensity Signals on T1-Weighted MR Imaging: Relation to Plaque Morphology and Clinical Severity of Angina Pectoris. JACC Cardiovasc Imaging. 2015 Oct;8(10):1143-1152. doi: 10.1016/j.jcmg.2015.06.013. Epub 2015 Sep 9.
March 24, 2020
Actual (reported)Study Completion
March 24, 2020
Actual (reported)Last Updated
May 21, 2024
Record last verified: 2024-05
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Source: ClinicalTrials.gov.
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