INTUBE
INternational Observational Study To Understand the Impact and BEst Practices of Airway Management in Critically Ill Patients
Sponsor study identifier
observational
3,600
1 country
1
Study Start
October 1, 2018
Actual (reported)Primary Completion
July 31, 2019
Actual (reported)Study Completion
September 30, 2019
Actual (reported)Endotracheal intubation (ETI) is a potentially life-threatening procedure for critically ill patients and major severe complications such as severe hypoxia, cardiovascular collapse and cardiac arrest are common. Despite the high risk of the procedure, different interventions lack high-quality evidence and the investigators hypothesize that a heterogeneous practice among different centres and geographical areas may be found. The investigators designed a large international observational study aiming at prospectively collecting data on the current impact of ETI-related adverse events and current airway management practice in critically ill patients. Investigators will collect data on all consecutive in-hospital (intensive care unit, emergency department and wards) ETIs performed in adult critically patients.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 30, 2019
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 15, 2018
Actual (reported)August 6, 2018
Actual (reported)October 1, 2018
Actual (reported)July 31, 2019
Actual (reported)September 30, 2019
Actual (reported)Major intubation-related complication
At least one of the following (composite outcome): * Severe hypoxemia (SpO2 \< 80%) occurring within 30 minutes from intubation * Cardiac arrest occurring within 30 minutes from intubation * Cardiovascular collapse (at least one of the following), occurring within 30 minutes from intubation: * Systolic arterial pressure \< 65 mmHg recorded 1 time * SAP \< 90 mmHg for \> 30 minutes * New need of vasopressors/their increase and/or fluid load \> 15 ml/kg to maintain the target blood pressure.
30 minutes
Cardiac arrhythmia
30 minutes
Difficult intubation
30 minutes
Cannot intubate cannot oxygenate scenario (CICO)
30 minutes
Emergency front of neck airway (FONA)
30 minutes
Aspiration of gastric contents
24 hours
We will include all adult (≥ 18 years old) critically ill patients undergoing intubation during the period of observation. We will consider all in-hospital intubations. We will define critically ill those patients with a life-threatening condition requiring intubation for either cardiorespiratory failure or airway protection.
ASST Monza - University Hospital San Gerardo
Monza, Italy
Russotto V, Laffey JG, Tassistro E, Myatra SN, Rezoagli E, Foti G, Antolini L, Valsecchi MG, Bauer PR, Szuldrzynski K, Camporota L, Greif R, Higgs A, Parotto M, Fumagalli R, Sorbello M, Robba C, Grasselli G, Bellani G, Caironi P, Lascarrou JB; INTUBE Study Investigators. Peri-intubation complications in critically ill obese patients: a secondary analysis of the international INTUBE cohort. Crit Care. 2025 May 13;29(1):192. doi: 10.1186/s13054-025-05419-2.
Russotto V, Lascarrou JB, Tassistro E, Parotto M, Antolini L, Bauer P, Szuldrzynski K, Camporota L, Putensen C, Pelosi P, Sorbello M, Higgs A, Greif R, Grasselli G, Valsecchi MG, Fumagalli R, Foti G, Caironi P, Bellani G, Laffey JG, Myatra SN; INTUBE Study Investigators. Efficacy and adverse events profile of videolaryngoscopy in critically ill patients: subanalysis of the INTUBE study. Br J Anaesth. 2023 Sep;131(3):607-616. doi: 10.1016/j.bja.2023.04.022. Epub 2023 May 17.
Vincenzo Russotto, MD
Department of Emergency and Intensive Care, University Hospital San Gerardo Monza, ASST Monza, Monza, Italy
Giacomo Bellani, MD, PhD
Department of Emergency and Intensive Care, University Hospital San Gerardo Monza, ASST Monza, Monza, Italy; University of Milano Bicocca
3,600 participants (actual enrollment reported by the registry).
First Submitted
July 15, 2018
First Posted
August 6, 2018
Study Start
October 1, 2018
Actual (reported)Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation
Contact the study team to confirm eligibility.
Russotto V, Tassistro E, Myatra SN, Parotto M, Antolini L, Bauer P, Lascarrou JB, Szuldrzynski K, Camporota L, Putensen C, Pelosi P, Sorbello M, Higgs A, Greif R, Pesenti A, Valsecchi MG, Fumagalli R, Foti G, Bellani G, Laffey JG. Peri-intubation Cardiovascular Collapse in Patients Who Are Critically Ill: Insights from the INTUBE Study. Am J Respir Crit Care Med. 2022 Aug 15;206(4):449-458. doi: 10.1164/rccm.202111-2575OC.
Primary Completion
July 31, 2019
Actual (reported)Study Completion
September 30, 2019
Actual (reported)Last Updated
February 13, 2020
Record last verified: 2020-02
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