NCT03615781|Completed
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Sponsor study identifier
interventional
85
1 country
1
Study Start
June 1, 2015
Actual (reported)Primary Completion
April 1, 2018
Actual (reported)Study Completion
May 18, 2018
Actual (reported)The optimal duration of systemic antibiotic administration for native joint septic arthritis is unknown. The investigators perform a randomized study allowing up to 3 surgical lavages and allocating patients into a two-week's and a four week's randomization arm
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 18, 2018
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 1, 2015
Actual (reported)January 16, 2017
Actual (reported)April 1, 2018
Actual (reported)May 18, 2018
Actual (reported)August 6, 2018
Actual (reported)Clinical Remission of systemic infection
Measurement of fever.
6 months
Sequels
Patient's remaining gait disorders. * range of movement in adjacent joints of former infection * questionnaire regarding persistant pain and handicaps (open wording)
6 months
Wound redness
6 months
Wound discharge
6 months
Presence of pus
6 months
The investigators perform a surgical drainage and removal of the infected orthopedic implant.
The investigators surgically remove the infected implant.
The investigators perform a surgical drainage and removal of the infected orthopedic implant. They start an empirical antibiotic treatment based on patient's history and co-morbidities, such as vancomycin or amoxicillin/clavulanic acid. The adapt later on the targeted antibiotic therapy according to the causative pathogens and their antibiotic susceptibility testing.
The investigators perform a surgical drainage of the infection along with the complete removal of the infected orthopedic implant.
The investigators perform a surgical drainage of the infection along with the complete removal of the infected orthopedic implant.
Geneva University Hospitals
Geneva, 1211, Switzerland
Uckay I, Tovmirzaeva L, Garbino J, Rohner P, Tahintzi P, Suva D, Assal M, Hoffmeyer P, Bernard L, Lew D. Short parenteral antibiotic treatment for adult septic arthritis after successful drainage. Int J Infect Dis. 2013 Mar;17(3):e199-205. doi: 10.1016/j.ijid.2011.12.019. Epub 2012 Nov 22.
Gjika E, Beaulieu JY, Vakalopoulos K, Gauthier M, Bouvet C, Gonzalez A, Morello V, Steiger C, Hirsiger S, Lipsky BA, Uckay I. Two weeks versus four weeks of antibiotic therapy after surgical drainage for native joint bacterial arthritis: a prospective, randomised, non-inferiority trial. Ann Rheum Dis. 2019 Aug;78(8):1114-1121. doi: 10.1136/annrheumdis-2019-215116. Epub 2019 Apr 16.
Ilker Uçkay, MD
University Hospital, Geneva
85 participants (actual enrollment reported by the registry).
First Submitted
January 16, 2017
First Posted
August 6, 2018
Study Start
June 1, 2015
Actual (reported)Short Term Results of Pediatric Septic Hip Arthritis Management in Assiut University Hospitals
The investigators surgically remove the infected implant and all soft tissue infection. Instead of a total of 2 week's of antibiotic therapy, they administer a total of 4 weeks of systemic antibiotic therapy targeted to the pathogen(s).
After the surgical implant removal, the investigators prescribe a total of 2 weeks of systemic targeted antibiotic therapy against the causative pathogen(s), of which one week is recommended to be intravenously.
After the surgical implant removal, the investigators prescribe a total of 4 weeks of systemic targeted antibiotic therapy against the causative pathogen(s), of which one week is recommended to be intravenously.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Primary Completion
April 1, 2018
Actual (reported)Study Completion
May 18, 2018
Actual (reported)Last Updated
August 6, 2018
Record last verified: 2018-07
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Source: ClinicalTrials.gov.
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