Predicting Long-term Outcomes After Cardiac Arrest by Using Serum NGAL

NCT03615300 | Terminated

• 1 other identifier: UC18OESI0055
• Study Type: observational
• Target: 73
• Locations: 1 country
• Sites: 1

Brief Summary

This study was performed to determine the prognosis of patients after cardiac arrest using serum markers called NGAL. The initial NGAL values of patients with post-cardiac arrest syndrome are checked by blood tests, and the long-term neurological prognosis and survival rate are collected after 6 months.

Conditions

Out-of-Hospital Cardiac Arrest

Outcome Measures

Primary Outcomes (1)

• Long term neurologic outcome

  Patients' CPC score after 6 months (good outcome : CPC score 1, 2 / poor outcome : CPC score 3, 4, 5)

  6 months

Secondary Outcomes (1)

• Proportion of participants with Overall Survival at 6 months

  6 months

Study Arms (2)

good neurologic outcome

Patients with good neurological prognosis after 6 months (CPC 1, 2). serum NGAL is collected.

Diagnostic Test: serum NGAL

poor neurologic outcome

Patients with poor neurological prognosis after 6 months (CPC 3, 4, 5). serum NGAL is collected.

Diagnostic Test: serum NGAL

Interventions

serum NGAL DIAGNOSTIC_TEST

serum NGAL was measured at 0, 24, 48, and 72 hours after recovery of spontaneous circulation.

good neurologic outcome; poor neurologic outcome

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult survivors after out-of-hopital cardiac arrest who underwent targeted temperature management and survived longer than 3 days.

You may qualify if:

• Adult patients who underwent targeted temperature management after out-of-hospital cardiac arrest.

You may not qualify if:

• Patients who did not survived 3 days after cardiac arrest.
• Pre-existing end-stage renal disease or dependence on renal replacement therapy

Sponsors & Collaborators

• Uijeongbu St. Mary Hospital: lead

Study Sites (1)

Uijeongbu St. Mary's Hospital

Uijeongbu-si, Gyeonggi-do, 11765, South Korea

Location

Related Publications (2)

• Elmer J, Jeong K, Abebe KZ, Guyette FX, Murugan R, Callaway CW, Rittenberger JC; Pittsburgh Post-Cardiac Arrest Service. Serum Neutrophil Gelatinase-Associated Lipocalin Predicts Survival After Resuscitation From Cardiac Arrest. Crit Care Med. 2016 Jan;44(1):111-9. doi: 10.1097/CCM.0000000000001357.

  PMID: 26457752 BACKGROUND

• Park YR, Oh JS, Jeong H, Park J, Oh YM, Choi S, Choi KH. Predicting long-term outcomes after cardiac arrest by using serum neutrophil gelatinase-associated lipocalin. Am J Emerg Med. 2018 Apr;36(4):660-664. doi: 10.1016/j.ajem.2017.12.013. Epub 2017 Dec 7.

  PMID: 29317152 RESULT

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum

MeSH Terms

Conditions

Out-of-Hospital Cardiac Arrest

Condition Hierarchy (Ancestors)

Heart Arrest; Heart Diseases; Cardiovascular Diseases

Study Officials

• Joo Suk Oh, MD PhD

  The Catholic University of Korea, Uijeongbu ST. Mary's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 30, 2018
• First Posted: August 3, 2018
• Study Start: June 28, 2018
• Primary Completion: May 1, 2022
• Study Completion: May 1, 2022
• Last Updated: May 13, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)