Effects of Propofol Induction Anaesthesia on the Heart Rate Variability

NCT03613961 | Completed DMC

• 1 other identifier: VGHTPE
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The ANS plays an important role in the regulation of hemodynamics during anesthesia. Manually blous of propofol during induction anesthesia is reported to reduce both sympathetic and parasympathetic tone; however, it is not clear whether the changes in heart rate variability are associated with propofol concentration.

Conditions

Autonomic Nervous System Imbalance

Outcome Measures

Primary Outcomes (1)

• HRV dynamics

  Evaluate the changes in heart rate variability at different propofol concentration

  2 minutes

Interventions

Anesthetics DRUG

The ANS plays an important role in the regulation of hemodynamics during anesthesia. Manually blous of propofol during induction anesthesia is reported to reduce both sympathetic and parasympathetic tone; however, it is not clear whether the changes in heart rate variability are associated with propofol concentration. We will observe the relationship of anesthetics and HRV dynamics.

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

patients scheduled for surgery under general anesthesia.

You may qualify if:

• The subjects were selected from patients scheduled for surgery under general anesthesia.

You may not qualify if:

• recent administration of sedative or opioid drugs, emergency surgery and impairment of renal, hepatic, cardiac or respiratory function.

Sponsors & Collaborators

• National Central University: lead

Study Sites (1)

Taipei Veterans General Hospital

Taipei, R.o.c, 11217, Taiwan

Location

Related Publications (1)

• Wang HY, Lo MT, Chen KH, Mandell S, Chang WK, Lin C, Ting CK. Strong Early Phase Parasympathetic Inhibition Followed by Sympathetic Withdrawal During Propofol Induction: Temporal Response Assessed by Wavelet-Based Spectral Analysis and Photoplethysmography. Front Physiol. 2021 Sep 13;12:705153. doi: 10.3389/fphys.2021.705153. eCollection 2021.

  PMID: 34588990 DERIVED

MeSH Terms

Interventions

Anesthetics

Intervention Hierarchy (Ancestors)

Central Nervous System Depressants; Physiological Effects of Drugs; Pharmacologic Actions; Chemical Actions and Uses; Central Nervous System Agents; Therapeutic Uses

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Taipei Veterans General hospital, attending doctor of anesthesiology

Study Record Dates

• First Submitted: July 29, 2018
• First Posted: August 3, 2018
• Study Start: July 25, 2017
• Primary Completion: July 1, 2018
• Study Completion: July 1, 2018
• Last Updated: January 9, 2020

Record last verified: 2020-01

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)