Artificial Intelligence Screening on Patients With Primary Angle Closure Glaucoma

NCT03611387 | Unknown DMC

• 1 other identifier: CCPMOH2018-China-4
• Study Type: observational
• Target: 1,500
• Locations: 1 country
• Sites: 1

Brief Summary

The Tomey CASIA (Tomey Corporation, Nagoya, Japan) is a novel rapid imaging device that captures high-quality imaging of the entire anterior chamber of the eye over detailed imaging of a single section. In this prospective study, we want to investigate and compare the anatomical structure of the drainage angle of the eye in patients with different types glaucoma using Tomey machine. This study gives us a better understanding of the predictability, validity and accuracy of Tomey machine in the diagnosis of different types of glaucoma. Moreover, the data collected here will be used to create an artificial intelligence (AI) platform to screen certain type of glaucoma.

Conditions

Ophthalmopathy

Keywords

Primary Angle-Closure Glaucoma; Artificial Intelligence

Outcome Measures

Primary Outcomes (2)

• The accuracy of the CASIA 2 OCT

  To compare the clinical applicability, accuracy, and validity of the CASIA 2 OCT (Tomey, Nagoya, Japan) in the assessment of anterior chamber angle of the eye in the glaucomatous patients withconventional imaging methods.

  baseline

• The sensitivity and specificity of the AI

  To create an AI program to reliably screen patients with certain type of glaucoma (such as primary angle closure glaucoma, PACG) using images from CASIA 2 OCT. To test the sensitivity and specificity of the AI program to screen patients with glaucoma using images from CASIA 2 OCT. Another database comprised of CASIA 2 OCT images will be created and used to test the AI program. The diagnosis based on the AI program will be compared with diagnosis from glaucoma specialist.

  baseline

Study Arms (3)

Normal

Patients without any type of glaucoma

Device: CASIA 2 OCT

Primary angle closure glaucoma

Patients with primary angle closure glaucoma

Device: CASIA 2 OCT

Primary open-angle glaucoma

Patients with primary open-angle glaucoma

Device: CASIA 2 OCT

Interventions

CASIA 2 OCT DEVICE

Using CASIA 2 OCT to assess the anterior chamber angle of the eye in the glaucomatous patients withconventional imaging methods

Normal; Primary angle closure glaucoma; Primary open-angle glaucoma

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Outpatients ≥18 years old with or without glaucoma

You may qualify if:

• Patient with or without glaucoma

You may not qualify if:

• Patients with any history of eye surgery (except cataract surgery) including laser procedure.
• Age \< =18 years

Sponsors & Collaborators

• Sun Yat-sen University: lead
• University of California: collaborator

Study Sites (1)

Zhognshan Ophthalmic Center, Sun Yat-sen University

Guangzhou, Guangdong, 510060, China

RECRUITING

MeSH Terms

Conditions

Eye Diseases; Glaucoma, Angle-Closure

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension

Central Study Contacts

Jing Li, M.D

CONTACT

+86-20-87330341; Reviewborad_SYsU@163.com

Haotian Lin, M.D,Ph.D

CONTACT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: July 26, 2018
• First Posted: August 2, 2018
• Study Start: April 1, 2018
• Primary Completion: December 31, 2019
• Study Completion: December 31, 2019
• Last Updated: August 2, 2018

Record last verified: 2018-07

Locations

CN (1)