Diagnosis and Management of Arterial Hypertension for Algerian Patients in Current Medical Practice

NCT03607812 | Completed

• 1 other identifier: ASDZ_Obs_01_2017
• Study Type: observational
• Target: 1,027
• Locations: 1 country
• Sites: 1

Brief Summary

Blood pressure reduction and control are associated with reduced risk of stroke and cardiovascular disease. There is evidence that ambulatory blood pressure monitoring (ABPM) results more accurately reflect the risk of cardiovascular events than do office measurements of blood pressure. New international guidelines recognize the importance of ABPM which has an important and growing role in the diagnosis and in guiding antihypertensive therapy. In 2011 in the United Kingdom, the National Institute for Health and Care Excellence (NICE) recommended that ABPM be performed on all patients with suspected hypertension to confirm the diagnosis and reduce unnecessary treatment in people who do not have true hypertension. The aim of this observational study is to describe the utility of ABPM generally and specifically in the management of hypertension by Cardiologists in the Algerian context.

Conditions

Arterial Hypertension

Keywords

Hypertension; ABPM

Outcome Measures

Primary Outcomes (1)

• Diagnosis of hypertension

  Valid 24h-ABPM: blood pressure ≥ 140/90 mmHg

  At 24 hours after the inclusion in the study (Visit 2)

Secondary Outcomes (4)

• Patient Demography

  At the Inclusion in the study

• Therapeutic Decison

  At 24 hours after the inclusion in the study (Visit 2)

• Self-measurement of Arterial blood Pressure

  At 6 weeks after the inclusion in the study (Visit 3)

• Evaluation of Compliance to treatment

  At 6 weeks after the inclusion in the study (Visit 3)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

In this observational study the target population will be constituted of patients who can benefit from the contribution of ABPM to confirm or refute (white coat effect) hypertension.

You may qualify if:

• Patients who are either hypertensive (defined as those with a clinic SBP ≥ 140 mmHg or DBP ≥ 90 mmHg \[7\]) or referred for the assessment of hypertension
• Informed consent obtained before any study-related activity

You may not qualify if:

• ABPM contraindication
• Patient with psychiatric disorder
• Patient not able to comply with study-related procedures based on clinical judgement of the investigator

Sponsors & Collaborators

• Merinal Laboratoires: lead
• Axelys Sante Dz: collaborator

Study Sites (1)

Service de cardiologie EHS Maouche ( ex CNMS de Benaknoun)

Algiers, Algeria

Location

Related Publications (7)

• Nansseu JR, Noubiap JJ, Mengnjo MK, Aminde LN, Essouma M, Jingi AM, Bigna JJ. The highly neglected burden of resistant hypertension in Africa: a systematic review and meta-analysis. BMJ Open. 2016 Sep 20;6(9):e011452. doi: 10.1136/bmjopen-2016-011452.

  PMID: 27650760 BACKGROUND

• Nibouche WN, Biad A. [Arterial hypertension at the time of diagnosis of type 2 diabetes in adults]. Ann Cardiol Angeiol (Paris). 2016 Jun;65(3):152-8. doi: 10.1016/j.ancard.2016.04.017. Epub 2016 May 24. French.

  PMID: 27234335 BACKGROUND

• Amrani A, Baba Hamed MB, Mesli Talebbendiab F. Association study between some renin-angiotensin system gene variants and essential hypertension in a sample of Algerian population: case control study. Ann Biol Clin (Paris). 2015 Sep-Oct;73(5):557-63. doi: 10.1684/abc.2015.1069.

  PMID: 26489814 BACKGROUND

• Ghembaza MA, Senoussaoui Y, Tani MK, Meguenni K. Impact of patient knowledge of hypertension complications on adherence to antihypertensive therapy. Curr Hypertens Rev. 2014;10(1):41-8. doi: 10.2174/157340211001141111160653.

  PMID: 25392143 BACKGROUND

• Lardjam-Hetraf SA, Mediene-Benchekor S, Ouhaibi-Djellouli H, Meroufel DN, Boulenouar H, Hermant X, Hamani-Medjaoui I, Saidi-Mehtar N, Amouyel P, Houti L, Goumidi L, Meirhaeghe A. Effects of established blood pressure loci on blood pressure values and hypertension risk in an Algerian population sample. J Hum Hypertens. 2015 May;29(5):296-302. doi: 10.1038/jhh.2014.81. Epub 2014 Sep 18.

  PMID: 25231511 BACKGROUND

• Bachir Cherif A, Temmar M, Labat C, Atif L, Chibane A, Benkhedda S, Taleb A, Benfenatki N, Benetos A, Bouafia MT. [Cardiovascular morbimortality after a follow-up of six years in black hypertensive in South Algeria]. Ann Cardiol Angeiol (Paris). 2014 Jun;63(3):168-75. doi: 10.1016/j.ancard.2014.04.019. Epub 2014 May 15. French.

  PMID: 24933716 BACKGROUND

• Hammoudi-Bendib N, Manamani L, Ouabdesselam S, Ouamer DS, Ghemri S, Courouve L, Cherif A, Mahi L, Benkhedda S. Ambulatory Blood Pressure Monitoring in the Diagnosis and Management of Arterial Hypertension in Current Medical Practice in Algeria. Curr Hypertens Rev. 2021;17(1):75-82. doi: 10.2174/1573402116666200324144223.

  PMID: 32208121 DERIVED

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 9, 2018
• First Posted: July 31, 2018
• Study Start: June 28, 2017
• Primary Completion: July 31, 2018
• Study Completion: August 31, 2018
• Last Updated: August 20, 2019

Record last verified: 2019-08

Locations

AL (1)