NCT03601845|Completed
MRE-IA in Liver Disease and Neurovascular Imaging
MRE-IA
Magnetic Resonance Elastography by Intrinsic Activation in Liver Disease and Neurovascular Imaging
Loading search results
MRE-IA
Magnetic Resonance Elastography by Intrinsic Activation in Liver Disease and Neurovascular Imaging
Sponsor study identifier
interventional
59
1 country
2
Study Start
January 31, 2019
Actual (reported)Primary Completion
July 1, 2019
Actual (reported)Study Completion
July 1, 2019
Actual (reported)The objective of this research project is to develop Magnetic Resonance Elastography by Intrinsic Activation (MRE-IA) imaging methods at two imaging centers (CRCHUS and CRCHUM) for use in ongoing studies in liver disease and neurovascular imaging. MRE is a developing MR imaging modality that provides detailed maps of tissue's mechanical properties, based on displacement measurements made during the propagation of low amplitude vibrations through the region of interest. MRE-IA uses the pressure pulses of the cardiac cycle to induce the vibrations needed for MRE image reconstruction. MRE-IA has already been demonstrated based on the use of existing, clinically approved MR imaging sequences, and once this capability has been established at the two centers, initial trials will be done to demonstrate the method's potential in liver and neurovascular imaging. In the case of the liver, this pilot project funding will be used to perform MRE-IA imaging in patients with chronic liver disease and focal liver lesions. Results will be analyzed to establish the relationship between the mechanical properties mentioned above and disease stage. In the neurovascular case, imaging will be conducted under basic visual and motor stimulus conditions in healthy subjects, and results compared non-stimulus control images to determine changes in the above properties based on brain function. In addition, MRE-IA images will be compared with BOLD imaging to investigate the role of fluid conductivity in fMRI results.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 1, 2019
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 18, 2018
Actual (reported)July 26, 2018
Actual (reported)January 31, 2019
Actual (reported)July 1, 2019
Actual (reported)July 1, 2019
Actual (reported)Elasticity of brain
Measure of elasticity of brain using iMRE
1 day During scheduled brain iMRE examination
Viscosity of brain
Measure of viscosity of brain using iMRE
1 day During scheduled brain iMRE examination
Porosity of brain
Measure of porosity of brain using iMRE
1 day During scheduled brain iMRE examination
Elasticity of liver
Measure of elasticity of liver using iMRE
1 day During scheduled brain iMRE examination
Viscosity of liver
Measure of viscosity of liver using iMRE
1 day During scheduled brain iMRE examination
Porosity of liver
Correlation between measures of poroviscoelasticity parameters of liver and histopathological features
1 day During scheduled brain iMRE examination
Repeatability of elasticity of liver
1 day During scheduled brain iMRE examination
Repeatability of viscosity of liver
1 day During scheduled brain iMRE examination
Repeatability of porosity of liver
1 day During scheduled brain iMRE examination
Additional sequencing only
Visual stimulation while using additional sequencing
Visual stimulation while using additional sequencing
Additional sequencing only
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
CRCHUM
Montreal, Quebec, H2X0C1, Canada
CRCHUS
Sherbrooke, Quebec, J1H 5N4, Canada
Van Houten Elijah, Ing., PhD
Centre hospitalier de l'Université de Sherbrooke
59 participants (actual enrollment reported by the registry).
First Submitted
June 18, 2018
First Posted
July 26, 2018
Study Start
January 31, 2019
Actual (reported)Measure of porosity of liver using iMRE
1 day During scheduled brain iMRE examination
Contact the study team to confirm eligibility.
Primary Completion
July 1, 2019
Actual (reported)Study Completion
July 1, 2019
Actual (reported)Last Updated
February 11, 2020
Record last verified: 2020-02
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: