Variables Predicting Reintubation After Thymectomy in Patients With Myasthenia Gravis

NCT03597373 | Unknown

• 1 other identifier: Reintubation
• Study Type: observational
• Target: 99
• Locations: 1 country
• Sites: 1

Brief Summary

Myasthenia gravis (MG) is an autoimmune disease that is characterized by muscle weakness and fatigue. The role of the thymus in MG has been suggested by the evidence that 10% to 15% of patients present with a thymoma and at least 60% with thymus hyperplasia or dysplasia.Beneficial effects of thymectomy in patients with MG have been described in 40% to 90%.Few studies have looked at the incidence of reintubation (not just within 24 hours after extubation), the factors associated with reintubation, and patient outcome. Premature extubation may lead to hypercarbia, hypoxemia, pulmonary hypertension, right heart failure, and myocardial ischemia. Additionally, it subjects the patient to the physical risks of reintubation, including esophageal intubation, laryngeal trauma, and pulmonary aspiration. The purpose of the present study was to determine the incidence of reintubation, the variables associated with reintubation, and patient outcome

Conditions

Myasthenia Gravis

Keywords

Prediction; Myasthenia gravis; Reintubation

Outcome Measures

Primary Outcomes (1)

• Risk Factors for Reintubation

  the reintubation rate was analyzed with logistic regression

  an average of 30 days

Study Arms (2)

reintubation

Reestablish of invasive mechanical ventilation

Other: reintubation

not reintubation

Favourable respiratory function

Other: reintubation

Interventions

reintubation OTHER

Reintubation was defied by the reinstitution of invasive mechanical ventilation following extubation at any time

not reintubation; reintubation

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients with myasthenia gravis undergoing thymectomy

You may qualify if:

• younger than 75 years
• absence of heart failure as the primary indication for mechanical ventilation •Acute Physiology and Chronic Health Evaluation (APACHE) II score less than 12 points on day of extubation
• body mass index less than 30

You may not qualify if:

• preoperative moderate-to-severe chronic obstructive pulmonary disease

Sponsors & Collaborators

• First Affiliated Hospital, Sun Yat-Sen University: lead

Study Sites (1)

Genglong Liu

Guangzhou, Guangdong, 510080, China

RECRUITING

MeSH Terms

Conditions

Myasthenia Gravis

Condition Hierarchy (Ancestors)

Paraneoplastic Syndromes, Nervous System; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Paraneoplastic Syndromes; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Neurodegenerative Diseases; Neuromuscular Junction Diseases; Neuromuscular Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Genglong Liu

  First Affiliated Hospital, Sun Yat-Sen University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Genglong Liu

CONTACT

+8615626405844; lglong3@mail2.sysu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 13, 2018
• First Posted: July 24, 2018
• Study Start: January 1, 2017
• Primary Completion: January 1, 2019
• Study Completion: January 1, 2019
• Last Updated: July 24, 2018

Record last verified: 2018-07

Locations

CN (1)