Nomograms to Precisely Predict Conditional Risk of Recurrence for Patients With Laryngeal Cancer

NCT03595410 | Unknown

• 1 other identifier: Laryngeal carcinoma
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Advanced laryngeal squamous cell carcinoma (SCC) remains a highly morbid and fatal disease despite aggressive interventions. Mortality is high in this cohort: laryngeal cancer affects over 13 000 patients in the United States, with over 3500 deaths annually.The results of the Veterans Affairs Cooperative Studies Program Laryngeal Cancer Trial and subsequent studies demonstrated similar overall survival (OS) rates for organ preservation protocols involving radiotherapy (RT) or chemoradiotherapy (CRT) when compared to surgery, with the benefit of preserving the larynx in a large majority of patients. As such, the use of RT or CRT has become the predominant initial intervention for patients with laryngeal SCC.6 However, the prognosis of recurrent and persistent laryngeal SCC is particularly dire.In this study, we sought to identify preoperative predictors of survival for patients with recurrent or persistent laryngeal SCC in order to set patient expectations and address modifiable risk factors. Identification of predictors of survival may also identify patients who could benefit from novel therapeutic agents in a neo/adjuvant fashion. Herein,we examine a cohort of patients with recurrent or persistent laryngeal SCC after definitive RT/CRT who has undergone total laryngectomy in order to identify potential preoperative predictors of clinical outcomes.

Conditions

Recurrent Laryngeal Cancer

Keywords

risk of recurrence; Nomograms; Laryngeal cancer

Outcome Measures

Primary Outcomes (1)

• Overall survival

  time from salvage laryngectomy to death from any cause

  Follow up 5 years

Study Arms (2)

Recurrence laryngeal cancer

Other: Recurrence laryngeal cancer

No recurrence laryngeal cancer

Other: Recurrence laryngeal cancer

Interventions

Recurrence laryngeal cancer OTHER

Recurrence laryngeal cancer has a wide range of invasion, rapid progression and poor prognosis.

No recurrence laryngeal cancer; Recurrence laryngeal cancer

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients with laryngeal cancer

You may qualify if:

• patients with a diagnosis of laryngeal squamous cell carcinoma

You may not qualify if:

• multiple primarry malignant neo-plasms

Sponsors & Collaborators

• First Affiliated Hospital, Sun Yat-Sen University: lead

Study Sites (1)

Genglong Liu

Guangzhou, Guangdong, China

RECRUITING

MeSH Terms

Conditions

Laryngeal Neoplasms

Condition Hierarchy (Ancestors)

Otorhinolaryngologic Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Neoplasms; Laryngeal Diseases; Respiratory Tract Diseases; Respiratory Tract Neoplasms; Otorhinolaryngologic Diseases

Study Officials

• Genglong Liu

  First Affiliated Hospital, Sun Yat-Sen University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Genglong Liu, MD

CONTACT

+8615626405844; lglong3@mail2.sysu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 13, 2018
• First Posted: July 23, 2018
• Study Start: January 1, 2017
• Primary Completion: January 1, 2020
• Study Completion: January 1, 2020
• Last Updated: July 23, 2018

Record last verified: 2018-07

Locations

CN (1)