Energy Availability in Female Athletes

NCT03593382 | Completed DMC

• 1 other identifier: B285
• Study Type: observational
• Target: 49
• Locations: 2 countries
• Sites: 3

Brief Summary

The purpose of this project is to study the impact of energy availability (EA) on female endurance athletes and the adaptive consequences of insufficient EA with a special reference to the impact on energy metabolism, reproductive-, vascular- and bone health as well as exercise capacity, neuromuscular performance, ability to recover from intense exercise and the genetic interaction. Specific aims:

• To investigate the effects of EA on energy metabolism
• To investigate the effects of EA on reproductive, vascular- and bone health, and endocrine functions
• To investigate the effects of EA on exercise capacity
• To investigate the effects of EA on neuromuscular performance
• To investigate the effects of EA on recovery after exercise
• To identify potential dietary factors influencing EA, exercise capacity and neuromuscular performance
• To identify potential exercise factors influencing EA, exercise capacity and neuromuscular performance
• To identify potential psychological, behavoural and motivational aspects associated with insufficient EA The investigators hypothesize that female athletes with insufficient energy availability have attenuated energy metabolism, reduced BMD, impaired endothelial function and decreased ability to recover between exercise bouts compared to matched controls with sufficient energy and nutrient intake. The investigators also hypothesize that EA influences exercise capacity and neuromuscular performance.

Conditions

Female Athlete Triad

Keywords

Female endurance athletes; Energy Availability; Nutrient Availability; Bone Mineral Density; Menstrual dysfunction; Female athlete triad; Energy metabolism; Recovery after exercise; Endothelial function; Eating disorders; Performance

Outcome Measures

Primary Outcomes (1)

• Energy availability

  Enenergy availability (kcal/kg FFM/day) was calculated as energy intake minus exercise energy expenditure relative to fat free mass based on the 7 day records of energy intake (kcal/day) and assessment of exercise energy expenditure (kcal/day) as well as the assessment of body composition at the first day of visit.

  Measurements performed once in the week after the two days of gynbaecological and physiological measurements

Secondary Outcomes (33)

• Resting energy metabolism

  Assessed once at the second visit which was between 6 weeks and 6 months after inclusion

• Work efficiancy

  Assessed once at the second visit which was between 6 weeks and 6 months after inclusion

• Substrate utilisation

  Substrate utilisation was assessed once at the second visit which was between 6 weeks and 6 months after inclusion

• Bone mineral content

  Bone mineral content was assessed once at the first visit which was between 6 weeks and 6 months after inclusion

• Bone mineral density

  Bone mineral density was assessed once at the first visit which was between 6 weeks and 6 months after inclusion

Study Arms (1)

Female endurance athletes

Female endurance athletes recruited from Swedish and Danish national teams and competitive sport clubs

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Female endurance athletes exercising minimum 5 times a week will be recruited via the Danish and Swedish National Sport Federations (Team Danmark, Danmarks Idrætsforbund and Riksidrottsförbundet) and from competivite sport clubs.

You may qualify if:

• Female endurance athlete exercising at least 5 times/week

You may not qualify if:

• Pregnancy
• Metabolic disorders
• Smoking
• Use of psychopharmaca
• Use of other forms of contraceptives than oral, e.g. hormonal coil or patches
• Serious injury stopping the athlete from training ≥ 2 weeks.
• Diabetes

Sponsors & Collaborators

• University of Copenhagen: lead
• Lund University: collaborator
• Herlev Hospital: collaborator

Study Sites (3)

Fertility Clinic Herlev Hospital

Herlev, Copenhagen, Denmark

Location

Department of Human Nutrition

Copenhagen, 1958, Denmark

Location

Lund University

Lund, Skåne County, Sweden

Location

Biospecimen

Retention: SAMPLES WITH DNA

Whole Blood Serum Plasma

MeSH Terms

Conditions

Female Athlete Triad Syndrome; Feeding and Eating Disorders

Condition Hierarchy (Ancestors)

Relative Energy Deficiency in Sport; Mental Disorders; Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Anders sjödin, Assoc prof

  Department of Human Nutrition, University of Copenhagen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 16, 2012
• First Posted: July 20, 2018
• Study Start: November 1, 2011
• Primary Completion: June 1, 2013
• Study Completion: December 1, 2013
• Last Updated: July 20, 2018

Record last verified: 2018-07

Locations

DK (2); SE (1)