NCT03592147

Brief Summary

While the stress response, characterised by an increase in heart rate, blood pressure, and cortisol, has evolved to ensure the survival of the organism in face of danger, chronic stress due to psychological stressors can be harmful. The opposite of the stress response is the "relaxation response". Mind-body techniques such as meditation, guided imagery and music therapy are thought to induce this response. The relaxation response is characterized as a wakeful hypometabolic state, where a decrease in central nervous system arousal is observed. Some studies reported a reduction in stress hormones, and in symptoms of anxiety and depression following the use of mind-body relaxation techniques. Other studies noted a reduction in stress measured using physiological measurements such as heart rate and blood pressure. Light therapy is another technique that is suggested to induce physiological changes similar to those seen in the relaxation response. Some studies have shown a reduction in heart rate, blood pressure, oxygen consumption and carbon dioxide production following exposure to blue light. These relaxation therapies can be useful for the general population and for vulnerable groups where alternative therapies, such as medication and psychotherapy, are difficult. Limited amount of studies have quantified the decrease in stress in physiological measurements such as heart rate and blood pressure. The aim of this study is to investigate which relaxation technique among five different interventions (and one control) is the most effective in improving relaxation and reducing stress in adult women of reproductive age (18-45 years). The results of this study will be used to inform the intervention of a study testing the impact of relaxation therapy on breastfeeding outcomes in mothers of late preterm infants.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
17

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Apr 2018

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 13, 2018

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 4, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 4, 2018

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

July 5, 2018

Completed
14 days until next milestone

First Posted

Study publicly available on registry

July 19, 2018

Completed
Last Updated

July 19, 2018

Status Verified

July 1, 2018

Enrollment Period

2 months

First QC Date

July 5, 2018

Last Update Submit

July 18, 2018

Conditions

Keywords

MeditationMusicRelaxationLight TherapyStress

Outcome Measures

Primary Outcomes (4)

  • Perceived Relaxation

    Perceived relaxation was assessed using a visual analogue scale (VAS), which is a 10 cm horizontal line spanning from the minimum to the maximum of the variable measured. The minimum (left) represents "completely unrelaxed" and the maximum (right) "completely relaxed". The women mark a point on the scale to indicate their feelings of relaxation. The distance between the mark and the minimum point was measured in centimetres (two decimal points).

    Post-intervention, an average of 10 mins

  • Blood Pressure

    Systolic and diastolic blood pressure (mmHg) were measured three times using a digital sphygmomanometer.

    Post-intervention, an average of 10 mins

  • Heart Rate

    Heart rate (bpm) was measured three times using a digital sphygmomanometer.

    Post-intervention, an average of 10 mins

  • Fingertip Temperature

    A non-contact digital thermometer was used to measure fingertip temperature as an indication of sympathetic nervous system activation.

    Post-intervention, an average of 10 mins

Secondary Outcomes (1)

  • Preference

    At the end of the study, at approximately 3-6 weeks

Study Arms (1)

Relaxation

OTHER

This is a within-subject pilot study, where each participant received, in random order, five different relaxation therapies (Guided Imagery Relaxation Tape, Music Listening, Relaxation Lighting, Meditation and Relaxation Light, and Music and Relaxation Light) and one Control/Silence state spanning across 3-6 weeks.

Other: Guided Imagery Relaxation TapeOther: Music ListeningOther: Relaxation LightingOther: Meditation and Relaxation LightOther: Music and Relaxation LightOther: Control/Silence

Interventions

The meditation is approximately 7 minutes in duration.

Also known as: Mediation
Relaxation

Participants have the option of selecting one of the following music categories: New age, classical, and oriental. The songs were selected based on criteria established in a previous study to induce relaxation. All songs were also modified in length to be approximately 7 minutes in duration.

Also known as: Music
Relaxation

The participants were asked to select either orange or blue lighting settings using the Philips Hue lighting. The intensity of the light will be fixed to control for that measure. They were asked to sit for approximately 7 minutes in duration.

Relaxation

The guided imagery meditation and relaxation lighting were combined.

Relaxation

The music and relaxation lighting were combined.

Relaxation

The participants were asked to relax for a duration of 7 minutes, with no explicit advice given. Lighting was adjusted to a specific intensity and colour (basic yellow light) as was used in the music and guided imagery interventions.

Relaxation

Eligibility Criteria

Age18 Years - 45 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Women of reproductive age (18-45 years)
  • Fluent in English

You may not qualify if:

  • Any condition that may affect blood pressure, heart rate or energy expenditure i.e hypertension, hyperthyroidism, heart failure
  • Smokers
  • Recent surgeries or injuries

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University College London Great Ormond Street Institute of Child Health

London, WC1N 1EH, United Kingdom

Location

MeSH Terms

Conditions

Stress, Psychological

Interventions

Mediation AnalysisMusic TherapyMeditation

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehavior

Intervention Hierarchy (Ancestors)

Factor Analysis, StatisticalStatistics as TopicEpidemiologic MethodsInvestigative TechniquesHealth Care Evaluation MechanismsQuality of Health CareHealth Care Quality, Access, and EvaluationPublic HealthEnvironment and Public HealthSensory Art TherapiesComplementary TherapiesTherapeuticsRehabilitationAftercareContinuity of Patient CarePatient CarePsychotherapyBehavioral Disciplines and ActivitiesMind-Body TherapiesSpiritual TherapiesRelaxation TherapyBehavior Therapy

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Model Details: Within-subject pilot study, where each participant will undergo five different relaxation therapies (guided imagery meditation, music listening, "relaxation" lighting, combination of light and meditation, and a combination of light and music) and one silence/control state.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 5, 2018

First Posted

July 19, 2018

Study Start

April 13, 2018

Primary Completion

June 4, 2018

Study Completion

June 4, 2018

Last Updated

July 19, 2018

Record last verified: 2018-07

Locations