Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects.
PORTEAU
1 other identifier
interventional
22
1 country
1
Brief Summary
Hepatic artery and portal flows are both regulated to assume the whole hepatic blood flow. Each counts for respectively 25% and 75%. That so-called "buffer response" assumes that when portal flow increases, hepatic artery flow decreases. During fluid challenge in intensive care unit, fluid challenge is often administered to improve hepatic perfusion. That observation is not demonstrated. The aim of the study is to test buffer response and portal flow during fluid challenge.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Sep 2018
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 3, 2018
CompletedFirst Posted
Study publicly available on registry
July 17, 2018
CompletedStudy Start
First participant enrolled
September 6, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 29, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
March 29, 2019
CompletedSeptember 19, 2025
September 1, 2025
7 months
July 3, 2018
September 16, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Portal blood flow measure before and after fluid challenge
Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI (magnetic resonance imaging).
Two hours: the difference in hepatic portal flow before and after a volume expansion of 500 ml NaCl 0.9%.
Secondary Outcomes (1)
Hepatic artery blood flow measure before and after fluid challenge
Two hours
Other Outcomes (1)
Flow ratio of portal flow on hepatic artery flow
Two hours
Study Arms (1)
MRI (magnetic resonance imaging)
OTHERHepatic blood flow baseline will be measured using MRI. Fluid challenge of 500 ml of NaCl 0.9% will be administered during 10 minutes. Before and After fluid challenge, MRI will be performed to compare flow changes.
Interventions
Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI.
Eligibility Criteria
You may qualify if:
- Fasting for the last 12 hours.
You may not qualify if:
- Claustrophobia
- Any previous medical history disease;
- Any abdominal surgical disease
- Pregnancy or breastfeeding
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CHU Amiens-Picardie
Amiens, 80000, France
Related Publications (1)
Abou-Arab O, Beyls C, Moussa MD, Huette P, Beaudelot E, Guilbart M, De Broca B, Yzet T, Dupont H, Bouzerar R, Mahjoub Y. Portal Vein Pulsatility Index as a Potential Risk of Venous Congestion Assessed by Magnetic Resonance Imaging: A Prospective Study on Healthy Volunteers. Front Physiol. 2022 Apr 29;13:811286. doi: 10.3389/fphys.2022.811286. eCollection 2022.
PMID: 35574483RESULT
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 3, 2018
First Posted
July 17, 2018
Study Start
September 6, 2018
Primary Completion
March 29, 2019
Study Completion
March 29, 2019
Last Updated
September 19, 2025
Record last verified: 2025-09