Myoelectric Computer Interface to Reduce Muscle Co-activation After Stroke
1 other identifier
interventional
35
1 country
1
Brief Summary
This study examines whether in-lab training with a myoelectric-computer interface (MyCI) can reduce abnormal muscle co-activation after stroke.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable stroke
Started Jul 2014
Typical duration for not_applicable stroke
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2017
CompletedFirst Submitted
Initial submission to the registry
June 28, 2018
CompletedFirst Posted
Study publicly available on registry
July 9, 2018
CompletedApril 13, 2026
April 1, 2026
3.3 years
June 28, 2018
April 7, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Fugl-Meyer Assessment - Upper Extremity
Scale 0-66, total score
6 weeks
Secondary Outcomes (3)
Fugl-Meyer Assessment - Upper Extremity
10 weeks
Wolf Motor Function Test
6 and 10 weeks
Motor Activity Log
6 and 10 weeks
Other Outcomes (1)
Modified Ashworth Scale
6 and 10 weeks
Study Arms (3)
60-minute Isometric
EXPERIMENTAL60-min Isometric MyCI training: EMG-controlled game training for 60-minutes per session
90-minute Isometric
EXPERIMENTAL90-min Isometric MyCI training: EMG-controlled game training for 90-minutes per session
90-minute Movement
EXPERIMENTAL90-min movement MyCI training: EMG-controlled game training for 90-minutes per session
Interventions
EMG-controlled in-lab training with arm restrained for 60 minutes per session
EMG-controlled in-lab training with arm restrained for 90 minutes per session
EMG-controlled in-lab training without restraint for 90 minutes per session
Eligibility Criteria
You may qualify if:
- Stroke survivors at least 6 months after stroke onset
- Persistent moderate to severe arm impairment
- Increased arm tone
You may not qualify if:
- Substantial impairment of vision, memory, language or concentration
- Botulinum toxin use in the affected arm
- Concomitant participation in another research study on the arm
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Northwestern University
Chicago, Illinois, 60611, United States
Related Publications (2)
Mugler EM, Tomic G, Singh A, Hameed S, Lindberg EW, Gaide J, Alqadi M, Robinson E, Dalzotto K, Limoli C, Jacobson T, Lee J, Slutzky MW. Myoelectric Computer Interface Training for Reducing Co-Activation and Enhancing Arm Movement in Chronic Stroke Survivors: A Randomized Trial. Neurorehabil Neural Repair. 2019 Apr;33(4):284-295. doi: 10.1177/1545968319834903. Epub 2019 Mar 19.
PMID: 30888251RESULTSeo G, Kishta A, Mugler E, Slutzky MW, Roh J. Myoelectric interface training enables targeted reduction in abnormal muscle co-activation. J Neuroeng Rehabil. 2022 Jul 1;19(1):67. doi: 10.1186/s12984-022-01045-z.
PMID: 35778757DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Marc Slutzky, MD, PhD
Northwestern University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Masking Details
- Occupational Therapists were blinded to intervention group
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor of Neurology
Study Record Dates
First Submitted
June 28, 2018
First Posted
July 9, 2018
Study Start
July 1, 2014
Primary Completion
November 1, 2017
Study Completion
November 1, 2017
Last Updated
April 13, 2026
Record last verified: 2026-04