Effect of Total Knee Arthroplasty on Sarcopenia in Patients With Osteoarthritis in the Knee

NCT03579329 | Completed

• 1 other identifier: 2015.539
• Study Type: observational
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

Sarcopenia is a wasting disease with the locomotion system in the aged population. It is defined as the decline in muscle mass (lean body mass) and strength with the advance of age. The prevalence of sarcopenia increases with age, reaching an astounding 50% among the population aged over 75 in the United States. Sarcopenia is often associated with frailty, falls, and disability. Studies have found sarcopenia can be a predicting risk factor for fractures in the elderly. In addition, sarcopenia predicted a higher chance of mortality in nursing homes.

Conditions

Sarcopenia; Osteoarthritis, Knee

Keywords

sarcopenia; Osteoarthritis; Total Knee Arthroplasty

Outcome Measures

Primary Outcomes (2)

• International Physical Activity Questionnaire (IPAQ)

  Questionnaire

  one year

• DXA scan

  Lean Muscle Mass Index

  one year

Secondary Outcomes (2)

• Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

  one year

• Self-Rated 12

  one year

Interventions

Total Knee Arthroplasty PROCEDURE

Effect of Total Knee Arthroplasty on Sarcopenia in Patients with Osteoarthritis in the Knee

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

End stage knee osteoarthritis

You may qualify if:

• Male and Female aged over 18 wirh end stage knee OA
• Scheduled for TKA
• Agree to provide written consent

You may not qualify if:

• History of alcoholism or drug abuse
• Pregnancy and breast-feeding
• Presence of serious pathologies
• Steroid-based systemic therapy in progress or interrupted since less than 1 month
• With significant hematologic diseases

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong

Hong Kong, Hong Kong

Location

Related Publications (1)

• Ho KK, Lau LC, Chau WW, Poon Q, Chung KY, Wong RM. End-stage knee osteoarthritis with and without sarcopenia and the effect of knee arthroplasty - a prospective cohort study. BMC Geriatr. 2021 Jan 4;21(1):2. doi: 10.1186/s12877-020-01929-6.

  PMID: 33397330 DERIVED

MeSH Terms

Conditions

Sarcopenia; Osteoarthritis, Knee; Osteoarthritis

Interventions

Arthroplasty, Replacement, Knee

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Arthroplasty, Replacement; Arthroplasty; Orthopedic Procedures; Surgical Procedures, Operative; Plastic Surgery Procedures; Prosthesis Implantation

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professional Consultant

Study Record Dates

• First Submitted: June 26, 2018
• First Posted: July 6, 2018
• Study Start: April 30, 2020
• Primary Completion: February 2, 2022
• Study Completion: February 2, 2022
• Last Updated: March 22, 2022

Record last verified: 2022-03

Locations

HK (1)