Sugar-sweetened Beverages Influence Benefits of Exercise in Overweight Adults

NCT03576703 | Completed

• 1 other identifier: MW CTR-IN 15-746Q-MSU-PG21-00
• Study Type: interventional
• Target: 26
• Locations: 0 countries
• Sites: N/A

Brief Summary

The objective of this study was to determine how metabolic and inflammatory effects of physical exercise in overweight individuals are altered when sugar-sweetened beverages (SSB) are consumed after physical exercise. A randomized, controlled crossover trial was performed in which participants performed exercise with and without the ingestions of SSB during exercise or a non-exercise control condition to evaluate metabolic and inflammatory responses one day after the exercise and or SSB treatment.

Conditions

Inflammation; Insulin Sensitivity

Keywords

metabolic syndrome; inflammation; insulin sensitivity; metabolic flexibility; overweight/obese

Outcome Measures

Primary Outcomes (3)

• Glucose tolerance

  75 g oral glucose tolerance test with measurement of glucose and insulin

  2 hours

• Metabolic flexibility

  Change in respiratory exchange ratio in response to ingestion of 75 g of glucose

  2 hours

• Inflammation

  Change in cytokine and reactive oxygen species concentrations after ingestion of 75 g of glucose

  2 hours

Study Arms (3)

EX+H2O

EXPERIMENTAL

Exercise and diet that did not include SSB

Other: Exercise with and without SSB ingestion

EX+SSB

EXPERIMENTAL

Exercise and diet that includes SSB

Other: Exercise with and without SSB ingestion

CONTROL

NO INTERVENTION

No exercise and diet that did not include SSB

Interventions

Exercise with and without SSB ingestion OTHER

Consumption of a prescribed diet with and without SSB and performance of moderate aerobic exercise or resting/control

EX+H2O; EX+SSB

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI \> 25 and \< 35 kg/m2
• sedentary to moderately active

You may not qualify if:

• inflammatory conditions
• heart disease, diabetes, and other diseases that may interfere with the safety of exercise or other experimental procedures
• allergy to wheat, gluten, dairy, or peanuts
• taking blood pressure, cholesterol lowering, or anti-inflammatory medications
• taking hormone-based birth control with exception of intrauterine device,
• pregnant
• health concerns that make it difficult to participate in study procedures

Sponsors & Collaborators

• Montana State University: lead

MeSH Terms

Conditions

Inflammation; Insulin Resistance; Metabolic Syndrome; Overweight; Obesity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Mary P Miles, PhD

  Montana State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: randomized crossover

Study Record Dates

• First Submitted: June 26, 2018
• First Posted: July 3, 2018
• Study Start: October 24, 2014
• Primary Completion: July 9, 2015
• Study Completion: July 9, 2015
• Last Updated: July 3, 2018

Record last verified: 2018-06

Data Sharing

• IPD Sharing: Will not share