NCT03576079

Brief Summary

comparing the effects of Laser therapy with anterior re-positioning splint and a placebo group on clinical signs and symptoms of temporo-mandibular dis-function and assessing articular disc morphology and configuration with magnetic resonance imaging.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2015

Typical duration for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2015

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2017

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2018

Completed
8 days until next milestone

First Submitted

Initial submission to the registry

June 9, 2018

Completed
24 days until next milestone

First Posted

Study publicly available on registry

July 3, 2018

Completed
Last Updated

July 3, 2018

Status Verified

July 1, 2018

Enrollment Period

2.1 years

First QC Date

June 9, 2018

Last Update Submit

July 2, 2018

Conditions

Keywords

laser therapyanterior re-positioning splint

Outcome Measures

Primary Outcomes (1)

  • Level of temporomandibular joint pain: assessed by using subjective visual analogue scale

    current level of temporomandibular joint pain assessed by using subjective visual analogue scale from 1 to 10 according to the research diagnostic criteria of temporomandibular disorders diagnostic sheets, zero indicates no pain, while 10 indicates the worst pain

    3 months

Secondary Outcomes (3)

  • click: joint sound

    3 months

  • limitation of mandibular movements

    3 months

  • disc recapture

    3 months

Study Arms (3)

Laser therapy

EXPERIMENTAL

12 laser sessions over 3 months

Device: Laser therapy

anterior re-positioning splint therapy

ACTIVE COMPARATOR

anterior re-positioning splint worn for 8 hours during night time for 3 months

Device: anterior re-positioning splint

inactive laser therapy

PLACEBO COMPARATOR

placebo laser for 12 sessions over 3 months

Device: inactive Laser therapy

Interventions

epic model biolase with an output of 4W, 1800 J wavelength with a continuous Laser mode.

Also known as: low-level Laser therapy, Biolase laser device
Laser therapy

hard acrylic anterior re-positioning splint

Also known as: occlusal splint, TMD splint
anterior re-positioning splint therapy

sham Laser, with inactive beam

inactive laser therapy

Eligibility Criteria

Age18 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Patients having TMD in the form of disc displacement with reduction as verified from signs and symptoms during clinical examination and confirmed from the MRI.
  • Good general health: The patient must be medically free from any systemic disease or health problems.
  • Adult patients 18 years old and above.
  • No previous orthodontic treatment.
  • No previous TMJ treatment or surgery.

You may not qualify if:

  • Patients with multiple missing posterior teeth.
  • Muscle pain due to systemic disease.
  • Dental related pain.
  • Congenital abnormality, neoplasia or acute trauma.
  • Previous TMJ treatment or surgery.
  • Any medical condition that prohibits MRI acquisition.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Temporomandibular Joint Disorders

Interventions

Laser TherapyLow-Level Light TherapyOcclusal Splints

Condition Hierarchy (Ancestors)

Craniomandibular DisordersMandibular DiseasesJaw DiseasesMusculoskeletal DiseasesJoint DiseasesMuscular DiseasesStomatognathic Diseases

Intervention Hierarchy (Ancestors)

TherapeuticsAblation TechniquesSurgical Procedures, OperativePhototherapyOrthotic DevicesOrthopedic EquipmentSurgical EquipmentEquipment and Supplies

Study Officials

  • Mona S Fayed, PHD

    Professor of Orthodontics, Faculty of Dentistry, Cairo Universitye

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
assistant lecturer

Study Record Dates

First Submitted

June 9, 2018

First Posted

July 3, 2018

Study Start

September 1, 2015

Primary Completion

September 30, 2017

Study Completion

June 1, 2018

Last Updated

July 3, 2018

Record last verified: 2018-07