Abdominal Cutaneous Nerve Entrapment Syndrome

NCT03574727 | Completed

• 1 other identifier: 2017AN003
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

Nerve entrapment as a cause of chronic abdominal pain is frequently overlooked. A series of nerves pass through the muscles of the abdomen before reaching the skin to carry sensations. They can get trapped within the muscles leading to severe pain resulting in a condition known as Abdominal Cutaneous Nerve Entrapment Syndrome (ACNES). ACNES affects between 10-30% of patients with chronic abdominal wall pain. A definitive diagnosis of ACNES is obtained by anaesthetising these nerves. Initial management includes education and avoidance of known triggers. It is common practice to inject steroid with local anaesthetic during the diagnostic injections itself to prolong pain relief. Like other nerve entrapment conditions, this is also refractory to medical treatment. Hence repeated injections and nerve entrapment release surgery are commonly carried out. In Aberdeen, a number of patients have been treated for this condition. A cohort of patients have benefitted with injection alone while recurrence has been noted in patients who have undergone surgery. This project aims to gain more understanding about the clinical course of patients with suspected ACNES by evaluation of the clinic progress.

Conditions

Abdominal Pain; Abdominal Cutaneous Nerve Entrapment Syndrome

Outcome Measures

Primary Outcomes (1)

• Success rate of intervention

  An intervention either injection or surgery is classed as success when there is either a 2 point difference in the average pain scores pre and post intervention or more than 30% improvement as rated by the participant in the Brief Pain Inventory used for evaluating the pain baseline and follow-up.

  3 months

Interventions

Injection to or release of anterior cutaneous nerves PROCEDURE

Patients who have undergone at least one injection to the nerves

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Potential participants will be identified from the hospital electronic booking system. A list of patients between January 2010 and December 2015 and had injection for chronic abdominal wall pain will be invited for the study.

You may qualify if:

• Be aged 16 or over
• Be able to understand English
• Be able to give informed consent
• Be able to report on their health and pain status (neurologically stable)
• Should have undergone either injection or surgery for suspected ACNES

You may not qualify if:

• Patients will be excluded if they:
• Are not able to understand what is required of them
• Are not able to give informed consent

Sponsors & Collaborators

• University of Aberdeen: lead
• NHS Grampian: collaborator

Study Sites (1)

Aberdeen Royal Infirmary

Aberdeen, Scotland, AB25 2 ZN, United Kingdom

Location

Related Publications (1)

• Kanakarajan S, Dharmavaram S, Tadros A, Pushparaj H, Rose A. Abdominal cutaneous nerve entrapment syndrome: A cross sectional survey of treatment outcomes. Br J Pain. 2022 Oct;16(5):538-545. doi: 10.1177/20494637221101719. Epub 2022 May 20.

  PMID: 36389004 BACKGROUND

Related Links

• National Library of Medicine

MeSH Terms

Conditions

Abdominal Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Signs and Symptoms, Digestive

Study Officials

• Saravanakumar Kanakarajan, MD

  NHS Grampian

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 20, 2018
• First Posted: July 2, 2018
• Study Start: September 15, 2017
• Primary Completion: September 19, 2018
• Study Completion: September 19, 2018
• Last Updated: December 24, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)