Hemodynamic Correlates of Distinct Hypnotic States

NCT03568227 | Completed

• 1 other identifier: HypnoScienceMRI
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The investigation will assess the brain activation connectivity patterns associated with hypnosis and possible hypnotic sub-states by means of functional magnetic resonance imaging (fMRI). For that purpose, 50 healthy participants highly familiar with hypnosis (according to the OMNI-method) will be recruited and tested.

Conditions

Hypnosis

Keywords

Hypnosis; Neurophysiology; fMRI; Resting-State; Hypnotic Sub-States

Outcome Measures

Primary Outcomes (1)

• Differences in resting state functional connectivity (assessed using fMRI) between the four conditions (control state 1 & 2, hypnotic state 1 & 2)

  90 minutes

Secondary Outcomes (2)

• Differences in heart rate variability (assessed during fMRI measurements) between the four conditions (control state 1 & 2, hypnotic state 1 & 2)

  90 minutes

• Differences respiratory frequency (assessed during fMRI measurements) between the four conditions (control state 1 & 2, hypnotic state 1 & 2)

  90 minutes

Study Arms (1)

Healthy Subjects

EXPERIMENTAL

The study has a 2 (Intervention: Hypnosis, Control) x 2 (State: 1 \& 2) factorial within-subjects design, resulting in a total of 4 conditions. All volunteers participate at the 4 conditions in the same session.The order of the interventions is counterbalanced resulting in two possible sequences: Sequence 1: Hypnosis State 1, Hypnosis State 2, Control State 1, Control State 2 Sequence 2: Control State 1, Control State2, Hypnosis State 1, Hypnosis State 2 Volunteers will be randomly allocated to the two sequence types.

Procedure: Hypnosis; Procedure: Control

Interventions

Hypnosis PROCEDURE

The hypnosis intervention consists of two elements: A hypnotic induction and a hypnotic deepening. The induction aims at guiding the participant into the first hypnotic state (state 1). The participants will remain in this state for 10 minutes, the duration of the fMRI-scan. The hypnotic deepening guides the participants into a very deep hypnotic state (state 2). Participants also remain in this state for 10 minutes, during which their brain activity is measured using fMRI

Healthy Subjects

Control PROCEDURE

The control intervention consists of texts corresponding to the induction and deepening of the hypnosis intervention. They are matched in duration and consist of textually matched excerpts from www.wikipedia.org. Control induction will be presented, resulting in the control state 1 (10 min). Then the control deepening will be performed, leading to the control state 2 (10 minutes). During both control states the brain activity will be recorded using fMRI.

Healthy Subjects

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged between 18 and 65
• Proficient in German language
• Written informed consent after being informed
• Familiar with hypnotic states of OMNI-Hypnosis

You may not qualify if:

• Pre-existing neurological and/or psychiatric conditions
• History of brain injuries
• Alcohol and/or drug abuse
• Chronic diseases that require a permanent intake of drugs
• General contraindications for a participation on a MRI-Experiment (e.g. claustrophobia, pace maker, cochlea implants, insulin pumps)
• Hypersensitivity to loud noise
• Not being able to lie still during a longer period of time
• Foreign metallic objects in the body (e.g. gunshot wounds, metallic particles, metal implants, irremovable piercings)
• Pregnancy

Sponsors & Collaborators

• Mike Bruegger: lead

Study Sites (1)

University of Zurich

Zurich, 8032, Switzerland

Location

Related Publications (5)

• Elkins GR, Barabasz AF, Council JR, Spiegel D. Advancing research and practice: the revised APA Division 30 definition of hypnosis. Int J Clin Exp Hypn. 2015;63(1):1-9. doi: 10.1080/00207144.2014.961870.

  PMID: 25365125 BACKGROUND

• Jensen MP, Jamieson GA, Lutz A, Mazzoni G, McGeown WJ, Santarcangelo EL, Demertzi A, De Pascalis V, Banyai EI, Rominger C, Vuilleumier P, Faymonville ME, Terhune DB. New directions in hypnosis research: strategies for advancing the cognitive and clinical neuroscience of hypnosis. Neurosci Conscious. 2017;3(1):nix004. doi: 10.1093/nc/nix004. Epub 2017 Apr 12.

  PMID: 29034102 BACKGROUND

• McGeown WJ, Mazzoni G, Vannucci M, Venneri A. Structural and functional correlates of hypnotic depth and suggestibility. Psychiatry Res. 2015 Feb 28;231(2):151-9. doi: 10.1016/j.pscychresns.2014.11.015. Epub 2014 Dec 6.

  PMID: 25557062 BACKGROUND

• Terhune DB, Cleeremans A, Raz A, Lynn SJ. Hypnosis and top-down regulation of consciousness. Neurosci Biobehav Rev. 2017 Oct;81(Pt A):59-74. doi: 10.1016/j.neubiorev.2017.02.002. Epub 2017 Feb 4.

  PMID: 28174078 BACKGROUND

• Varga K, Kekecs Z, Myhre PS, Jozsa E. A Neutral Control Condition for Hypnosis Experiments: "Wiki" Text. Int J Clin Exp Hypn. 2017 Oct-Dec;65(4):429-451. doi: 10.1080/00207144.2017.1348833.

  PMID: 28836922 BACKGROUND

MeSH Terms

Interventions

Hypnosis

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Psychotherapy; Behavioral Disciplines and Activities

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Senior Researcher

Study Record Dates

• First Submitted: June 7, 2018
• First Posted: June 26, 2018
• Study Start: July 13, 2018
• Primary Completion: September 30, 2018
• Study Completion: September 30, 2018
• Last Updated: November 27, 2018

Record last verified: 2018-11

Locations

CH (1)