fNIRS in the Evaluation of Cognitive-motor Interference in Post-stroke Patients

NCT03559283 | Completed

• 1 other identifier: 87RC17_0074 (ICM AVC)
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates cognitive-motor interference in stroke patients who is responsible an alteration of spatio-temporal gait parameters. It's proved in the literature but the underlying pathophysiological mechanisms remain poorly understood. fNIRS is a functional imaging technique that evaluates this interference under optimal conditions. The purpose of this study is to evaluate the hemodynamic activity of the CPF in walking post-stroke patients under different DT conditions.

Conditions

D020521

Keywords

stroke, dual-task, gait parameters, fNIRS

Outcome Measures

Primary Outcomes (1)

• Cost of the Double Task

  the double task (DT) cost measured by the average difference in magnitude of hemodynamic responses in HbO2 at the CPF level obtained by the fNIRS between the DT high and low cognitive load.

  Day of the Inclusion

Secondary Outcomes (2)

• Impact of the double task on spatio-temporal parameters of walking and on cognition

  Day of the Inclusion

• Evaluate the asymmetry of cerebral activation in different walking conditions

  Day of the Inclusion

Study Arms (1)

Walking and Record Cortical Activity

EXPERIMENTAL

A sensor placement will be performed on the patient's forehead to record brain activity when walking, when performing a mental task, and when performing both tasks at the same time. In parallel, walking will be on a carpet that will record the spatio-temporal parameters of walking.

Diagnostic Test: Walking and Record Cortical Activity

Interventions

Walking and Record Cortical Activity DIAGNOSTIC_TEST

The cortical activity of each patient is recorded by NIRS under the following conditions: * Simple task : The patient walks on an electronic walking track (GAITRite system) over 10 meters. The data collected are the spatio-temporal parameters of walking. * Cognitive task alone : two conditions of the n-back test (1-back and 2-back) to study neural activities related to working memory. The duration of realization will be 30 seconds by condition and we retain the number of errors realized. * Double Task : Achievement of the motor task (10-meter walk) is performed at the same time as a "weak" cognitive task (1-back) and a "high" cognitive task (2-back). The spatio-temporal parameters and the number of errors are collected by the observer.

Walking and Record Cortical Activity

Eligibility Criteria

• Age: 55 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patient between 55 and 75 years old
• First stroke
• ischemic sylvian or hemorrhagic lobar deep respecting the frontal lobe, subacute phase (J15-J90),
• patient walking 10 meters.

You may not qualify if:

• Heminegligencia,
• a history of neurological pathologies, orthopedic pathologies, aphasia, cognitive disorders preceding stroke (dementia, head trauma), acute cardiovascular or respiratory pathologies.

Sponsors & Collaborators

• University Hospital, Limoges: lead

Study Sites (1)

University Hospital

Limoges, 87042, France

Location

Related Publications (1)

• Hermand E, Tapie B, Dupuy O, Fraser S, Compagnat M, Salle JY, Daviet JC, Perrochon A. Prefrontal Cortex Activation During Dual Task With Increasing Cognitive Load in Subacute Stroke Patients: A Pilot Study. Front Aging Neurosci. 2019 Jul 2;11:160. doi: 10.3389/fnagi.2019.00160. eCollection 2019.

  PMID: 31312136 RESULT

MeSH Terms

Conditions

Stroke

Interventions

Walking

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Locomotion; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Exercise; Motor Activity

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 6, 2018
• First Posted: June 18, 2018
• Study Start: November 26, 2018
• Primary Completion: June 26, 2019
• Study Completion: June 26, 2019
• Last Updated: March 27, 2026

Record last verified: 2019-06

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)