NCT03558932

Brief Summary

Obtaining pleural biopsies in cases of malignant mesothelioma to detect molecular mechnisms and signal transduction

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
20

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jan 2019

Longer than P75 for all trials

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 23, 2018

Completed
23 days until next milestone

First Posted

Study publicly available on registry

June 15, 2018

Completed
7 months until next milestone

Study Start

First participant enrolled

January 1, 2019

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2023

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2024

Completed
Last Updated

June 15, 2018

Status Verified

June 1, 2018

Enrollment Period

4.9 years

First QC Date

May 23, 2018

Last Update Submit

June 5, 2018

Conditions

Malignant Mesothelioma

Outcome Measures

Primary Outcomes (1)

  • Pleural biopsy

    Biopsy

    5 years

Other Outcomes (3)

  • Immunoblotting

    5 years

  • Cytometric analysis (FACS-based approaches)

    5 years

  • Live cell imaging for Ca2+-signaling

    5 years

Interventions

pleural biopsyDIAGNOSTIC_TEST

diagnostic sampling

Eligibility Criteria

Age18 Years - 89 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

mesothelioma

You may qualify if:

  • suspicion of mesothelioma
  • referral for diagnostic thoracoscopy

You may not qualify if:

  • contra-indication for thoracoscopy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Biospecimen

Retention: SAMPLES WITHOUT DNA

pleural biopsies

MeSH Terms

Conditions

Mesothelioma, Malignant

Condition Hierarchy (Ancestors)

MesotheliomaAdenomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasmsNeoplasms, MesothelialLung NeoplasmsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SitePleural NeoplasmsLung DiseasesRespiratory Tract Diseases

Study Officials

  • Jonas Yserbyt

    Catholic university Leuven

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Jonas Yserbyt

CONTACT

+32 16 34 68 01jonas.yserbyt@uzleuven.be

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

May 23, 2018

First Posted

June 15, 2018

Study Start

January 1, 2019

Primary Completion

December 1, 2023

Study Completion

June 1, 2024

Last Updated

June 15, 2018

Record last verified: 2018-06

Data Sharing

IPD Sharing
Will not share