NCT03553745

Brief Summary

The integrity of interoceptive networks is linked to resilience against depressive symptoms, whereas degradation of these networks is linked to apathy and deficits in emotion processing. The goal of this study is to compare two major styles of yoga and cardiovascular exercise through a 10-week training program to promote interoceptive awareness. The researchers hypothesize that improvement in affective symptomatology will be correlated with better interoceptive development. Changes in mood related symptoms and interoception will be assessed at baseline, week 12 and week 14, in a cohort of adults aged 18-55.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
71

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Mar 2018

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 1, 2018

Completed
Same day until next milestone

Study Start

First participant enrolled

March 1, 2018

Completed
3 months until next milestone

First Posted

Study publicly available on registry

June 12, 2018

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 23, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 23, 2021

Completed
Last Updated

February 25, 2021

Status Verified

February 1, 2021

Enrollment Period

3 years

First QC Date

March 1, 2018

Last Update Submit

February 23, 2021

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in Interoceptive Acuity

    Interoceptive acuity will be assessed at baseline, week 12 and week 14. Data collection at three time points will be used to assess changes in interoceptive acuity over the timeline.

    14 weeks

Secondary Outcomes (1)

  • Peripheral Inflammatory Markers of Stress by collecting Dried Blood Spot (DBS)

    14 weeks

Study Arms (3)

Gentle Yoga Program

EXPERIMENTAL

Program will meet twice a week for a 10-week period. Participants will be a part of gentle yoga sessions led by instructors specializing in the area.

Behavioral: Gentle Yoga Intervention

Rigorous Yoga Program

EXPERIMENTAL

Program will meet twice a week for a 10-week period. Participants will be a part of rigorous yoga sessions led by instructors specializing in the area.

Behavioral: Rigorous Yoga Intervention

Cardiovascular Exercise Program

EXPERIMENTAL

Program will meet twice a week for a 10-week period. Participants will be a part of cardiovascular exercise sessions led by instructors specializing in the area.

Behavioral: Physical Exercise Intervention

Interventions

10-week exercise program structured around gentle yoga practice.

Gentle Yoga Program

10-week exercise program structured around rigorous yoga practice.

Rigorous Yoga Program

10-week exercise program structured around cardiovascular exercise.

Cardiovascular Exercise Program

Eligibility Criteria

Age18 Years - 55 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • years of age
  • Have negative mood symptoms (depression, anxiety, stress)
  • Is healthy and independent enough in daily life to attend study classes

You may not qualify if:

  • Pregnant women or women who are planning to become pregnant during the study period
  • History of structural brain disease, mass lesion, stroke, epilepsy
  • History of addictive disorder or significant substance abuse
  • Neurological disorders or reversible causes of dementia
  • Suicidality or history of psychosis
  • Currently attending regular yoga or aerobic exercise practice, or participated in more than 6 formal meditation, aerobic, or yoga classes in the past 12 months
  • Self-reported cognitive impairment and other disorders which may preclude safe participation in the program including acute major depression, bipolar or severe personality disorder

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Massachusetts General Hospital

Boston, Massachusetts, 02129, United States

Location

Study Officials

  • Sara Lazar, PhD

    Massachusetts General Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

March 1, 2018

First Posted

June 12, 2018

Study Start

March 1, 2018

Primary Completion

February 23, 2021

Study Completion

February 23, 2021

Last Updated

February 25, 2021

Record last verified: 2021-02

Locations