The Long-Term Outcome of 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia: A Retrospective Study.
Sponsor study identifier
observational
38
1 country
1
Study Start
April 29, 2018
Actual (reported)Primary Completion
May 5, 2018
Actual (reported)Study Completion
May 5, 2018
Actual (reported)This study is designed to investigate the effectiveness and safety of 3D-CT-guided percutaneous radiofrequency thermocoagulation for the treatment of tumor-related trigeminal neuralgia.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 5, 2018
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 29, 2018
Actual (reported)May 5, 2018
Actual (reported)May 5, 2018
Actual (reported)May 21, 2018
Actual (reported)June 7, 2018
Actual (reported)Cumulative recurrence-free rate
The modified Barrow Neurological Institute (BNI) pain intensity score will be used to assess pain degree. Pain relief degree will be evaluated as BNI I= no pain without medication, BNI II= occasional pain, not require medication, BNI IIIa= no pain with medication, BNI IIIb= Controlled pain with medication, BNI IV= improved pain that inadequately controlled by medication, BNI IV= persistent pain that inadequately controlled by medication. A BNI grade that increased to IV-V from I-IIIb after operation was defined as recurrence.
The enrollment of our study began on March 1st 2007 and ended on 31st October 2017. All following-up has been finished before February 28th 2018.
Patient satisfaction
From pre-operation to 1 week after operation
Adverse events
The enrollment of our study began on March 1st 2007 and ended on 31st October 2017. All following-up has been finished before February 28th 2018.
This retrospective study was conducted in Beijing Tiantan Hospital between March 2007 and February 2018. The local ethics committee approved this study and exempted the informed consent before the collection of patient data. We enrolled a total of 38 patients who fulfilled all following criteria: age\>18 years; typical TN symptoms in the same lateral as intracranial tumors; uncontrolled symptoms or intolerable side effects of medication; and pain duration longer than 90 days. To confirm that the trigeminal pain was secondary to tumors, brain magnetic resonance imaging (MRI) was performed in advance. Patients with infection at the puncture site, coagulopathy, epilepsy, other causes of TN, a history of mental disorders or anesthetic drug abuse were excluded from this study.
Beijing Tiantan Hospital
Beijing, Beijing Municipality, 100050, China
Kim SK, Kim DG, Se YB, Kim JW, Kim YH, Chung HT, Paek SH. Gamma Knife surgery for tumor-related trigeminal neuralgia: targeting both the tumor and the trigeminal root exit zone in a single session. J Neurosurg. 2016 Oct;125(4):838-844. doi: 10.3171/2015.7.JNS15451. Epub 2016 Jan 22.
Cho KR, Lee MH, Im YS, Kong DS, Seol HJ, Nam DH, Lee JI. Gamma knife radiosurgery for trigeminal neuralgia secondary to benign lesions. Headache. 2016 May;56(5):883-889. doi: 10.1111/head.12801. Epub 2016 Apr 4.
Fang Luo, M.D.
Beijing Tiantan Hospital
38 participants (actual enrollment reported by the registry).
First Submitted
May 21, 2018
First Posted
June 7, 2018
Study Start
April 29, 2018
Actual (reported)Contact the study team to confirm eligibility.
Furtado SV, Hegde AS. Trigeminal Neuralgia Due to a Small Meckel's Cave Epidermoid Tumor: Surgery Using an Extradural Corridor. Skull Base. 2009 Sep;19(5):353-7. doi: 10.1055/s-0029-1220201.
Cheng TM, Cascino TL, Onofrio BM. Comprehensive study of diagnosis and treatment of trigeminal neuralgia secondary to tumors. Neurology. 1993 Nov;43(11):2298-302. doi: 10.1212/wnl.43.11.2298.
Khan N, Michael A, Choucair A, Bit-Ivan E. Trigeminal Ganglioneuroma: A Rare Case of Trigeminal Neuralgia Caused by Cerebellopontine Angle Tumor. World Neurosurg. 2017 Mar;99:811.e7-811.e10. doi: 10.1016/j.wneu.2016.12.085. Epub 2016 Dec 30.
Kobata H, Kondo A, Iwasaki K. Cerebellopontine angle epidermoids presenting with cranial nerve hyperactive dysfunction: pathogenesis and long-term surgical results in 30 patients. Neurosurgery. 2002 Feb;50(2):276-85; discussion 285-6. doi: 10.1097/00006123-200202000-00008.
Kanpolat Y, Savas A, Bekar A, Berk C. Percutaneous controlled radiofrequency trigeminal rhizotomy for the treatment of idiopathic trigeminal neuralgia: 25-year experience with 1,600 patients. Neurosurgery. 2001 Mar;48(3):524-32; discussion 532-4. doi: 10.1097/00006123-200103000-00013.
Fraioli B, Esposito V, Guidetti B, Cruccu G, Manfredi M. Treatment of trigeminal neuralgia by thermocoagulation, glycerolization, and percutaneous compression of the gasserian ganglion and/or retrogasserian rootlets: long-term results and therapeutic protocol. Neurosurgery. 1989 Feb;24(2):239-45. doi: 10.1227/00006123-198902000-00014.
Emril DR, Ho KY. Treatment of trigeminal neuralgia: role of radiofrequency ablation. J Pain Res. 2010 Dec 12;3:249-54. doi: 10.2147/JPR.S14455.
Primary Completion
May 5, 2018
Actual (reported)Study Completion
May 5, 2018
Actual (reported)Last Updated
June 7, 2018
Record last verified: 2018-06
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