Multidisciplinary Follow-up of Patients With Amyotrophic Lateral Sclerosis

NCT03536962 | Unknown

• 1 other identifier: NAC 11-062R
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Analyse a multidisciplinary follow-up of amyotrophic lateral sclerosis patients, monitored through a Cohort study at Geneva University Hospitals.

Conditions

Amyotrophic Lateral Sclerosis

Outcome Measures

Primary Outcomes (1)

• Longitudinal change of the revised Amyotrophic Lateral Sclerosis Functional rating scale in Amyotrophic Lateral Sclerosis patients

  Clinical evolution of Amyotrophic Lateral Sclerosis patients will be measured by the revised Amyotrophic Lateral Sclerosis Functional rating scale. This scale includes 12 questions covering 4 distinct domains: fine motor function, gross motor function, respiratory function and bulbar symptoms. Lower scores indicate higher disability.This score will be assessed every three months

  2012-2016

Secondary Outcomes (4)

• Correlation of walking speed measured by Timed Up and Go test and the Amyotrophic Lateral Sclerosis Functional rating scale (ALSFRS-R)

  2012-2016

• Longitudinal evolution of pulmonary function in ALS patients

  2012-2016

• Evolution of body mass composition measured by the Body Mass Index in ALS patients

  2012-2016

• Longitudinal evolution of inspiratory muscle strength in ALS patients

  2012-2016

Interventions

no intervention OTHER

no intervention

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients living in the Geneva area suffering from Amyotrophic Lateral Sclerosis or related disorders

You may qualify if:

• Amyotrophic Lateral Sclerosis fulfilling the El Escorial criteria (definite, probable, possible), primary lateral sclerosis, progressive muscular atrophy, progressive bulbar palsy

Sponsors & Collaborators

• Ruxandra Iancu Ferfoglia: lead

Study Sites (1)

Geneva University Hospital

Geneva, 1205, Switzerland

Location

Related Links

• Link to multidisciplinary consultation for motorneurone disease

MeSH Terms

Conditions

Amyotrophic Lateral Sclerosis

Condition Hierarchy (Ancestors)

Spinal Cord Diseases; Central Nervous System Diseases; Nervous System Diseases; Motor Neuron Disease; Neurodegenerative Diseases; TDP-43 Proteinopathies; Neuromuscular Diseases; Proteostasis Deficiencies; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Jean-Paul Janssens, MD

  University Hospital, Geneva

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Chief resident

Study Record Dates

• First Submitted: January 14, 2018
• First Posted: May 25, 2018
• Study Start: June 1, 2012
• Primary Completion: September 1, 2016
• Study Completion: October 1, 2018
• Last Updated: May 25, 2018

Record last verified: 2018-04

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)