Gall Bladder Status Among Children With Chronic Haemolytic Anemia

NCT03533322 | Unknown

• 1 other identifier: gallbladderstatusinchhemlytic
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Gall bladder status among children with chronic haemolytic anemia attending to Assuit University Children Hospital. Hemolysis is defined as the premature destruction of red blood cells (RBCs) (a shortened RBC life span). Anemia results when the rate of destruction exceeds the capacity of the marrow to produce RBCs. Normal RBC survival time is 110-120 days (half-life: 55-60 days), and thus, approximately 0.85% of the most senescent RBCs are removed and replaced each day. Patients with chronic haemolytic anemia are subjected to many complications of chronic haemolytic anemia e.g anemic heart failure, complications of blood transfusion as hepatitis and AIDS, hypersplenism, haemosiderosis ,among them there is incidence of gallbladder stone formation. This work aims to a) to determine the prevalence of gall bladder diseases among patient with chronic haemolytic anemia. b) to determine the risk factors of gall bladder diseases among patients with chronic haemolytic anemia.

Conditions

Gall Bladder Disease

Outcome Measures

Primary Outcomes (1)

• prevelance of gall bladder diseases in children with chronic hemolytic syndrome

  gall bladder diseases

  one year

Eligibility Criteria

• Age: 1 Year - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All patients admitted to Assiut university children Hospital 1 year study * 2.4.4 -Study tools (in detail, e.g., lab methods, instruments, steps, chemicals, …): Full clinical history including (age of onset of chronic haemolytic anemia- type of chronic haemolytic anemia -frequency of blood transfusion - use of hydroxy urea - splenectomy or not- frequency of admission) * Detailed clinical examination * Abdominal ultrasound * Plain KUB (kidney ureter bladder) x-rayif radiopaque stone. * Compelete blood count * Liver function test * C- reactive protein

You may qualify if:

• children between 1 :18 years known to have chronic haemolytic anemia.

You may not qualify if:

• children below 1 year and above 18 years children had past history of cholecystectomy

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Gallbladder Diseases

Condition Hierarchy (Ancestors)

Biliary Tract Diseases; Digestive System Diseases

Study Officials

• abelatif abdelmoez, professor

  assiut universitypediatric hospital

  PRINCIPAL INVESTIGATOR

• shereen galal, assistprof

  assiut universitypediatric hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

shohnda nazeir, master

CONTACT

01064195028; shahdmohammed2060@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Gall bladder status among children with chronic haemolytic anemia attending to Assiut University children hospital

Study Record Dates

• First Submitted: May 11, 2018
• First Posted: May 23, 2018
• Study Start: October 1, 2018
• Primary Completion: October 1, 2019
• Study Completion: October 1, 2019
• Last Updated: July 31, 2018

Record last verified: 2018-05