Predictors of Reactive Thrombocytosis in Critically Ill Septic Patients

NCT03531515 | Unknown

• 1 other identifier: 2018-26-MD-EXP
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Reactive or secondary thrombocytosis is defined as abnormally high platelet count (≥4,50,000 platelets per micro-liter) in the absence of chronic myeloproliferative disease. In critically ill patients reactive thrombocytosis is not uncommon during recovery phase and an association has been seen with poor outcome and increased risk of subsequent VTE. However, not all patients with infection respond with thrombocytosis. No study has enumerated the risk factors or predictors of reactive thrombocytosis in critically ill septic patients.

Conditions

Sepsis; Thrombocytosis; Critically Ill

Outcome Measures

Primary Outcomes (1)

• Reactive or secondary thrombocytosis in critically ill septic patients

  Reactive or secondary thrombocytosis (≥4,50,000 platelets per micro-liter) due to the sepsis

  From date of inclusion until the date of thrombocytosis or date of ICU discharge (death or alive), whichever came first, assessed up to 3 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All adult (≥18 years) ICU patients with the diagnosis of sepsis.

You may qualify if:

• All adult (≥18 years) ICU patients with the diagnosis of sepsis will be considered.

You may not qualify if:

• Age \<18 years
• Pregnancy
• H/O Malignancy
• Thrombocytosis at admission
• Primary thrombocytosis
• Post-splenectomy
• Chronic inflammatory disease (e.g. Connective tissue disorders, IBD, temporal arteritis)
• Known immunosupressive condition
• Chronic infectious diseases (e.g. tuberculosis, chronic pneumonitis)

Sponsors & Collaborators

• Sanjay Gandhi Postgraduate Institute of Medical Sciences: lead

Study Sites (1)

Department of Critical Care Medicine, SGPGIMS

Lucknow, Uttar Pradesh, 226014, India

RECRUITING

MeSH Terms

Conditions

Sepsis; Thrombocytosis; Critical Illness

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Blood Platelet Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Myeloproliferative Disorders; Bone Marrow Diseases; Disease Attributes

Study Officials

• Mohan Gurjar, MD, PDCC

  Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mohan Gurjar, MD, PDCC

CONTACT

915222495403; m.gurjar@rediffmail.com

Monalisa Nayak, MD

CONTACT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Month
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Additional Professor

Study Record Dates

• First Submitted: March 17, 2018
• First Posted: May 21, 2018
• Study Start: April 11, 2018
• Primary Completion: April 1, 2019
• Study Completion: April 1, 2019
• Last Updated: May 21, 2018

Record last verified: 2018-05

Locations

IN (1)