Effect of Pregabalin or Adductor Canal Block on Postoperative Analgesia

NCT03530280 | Completed

• 1 other identifier: pregabalin
• Study Type: interventional
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

arthroscopically Anterior Cruciate Ligament Reconstruction (ACL) under spinal anesthesia were included in this study.

Conditions

Postoperative Pain After Knee Arthroscopy

Keywords

pregabalin; adductor canal block; postoperative pain

Outcome Measures

Primary Outcomes (2)

• 11-point numerical rating scale (NRS)

  11-point numerical rating scale for pain (0='no pain' and 10='worst pain possible pain') were explained.

  24 hours

• tramadol consumption

  24 hours tramadol consumption will be recorded as milligrams

  24 hours

Study Arms (3)

pregabalin (lyrica)

ACTIVE COMPARATOR

pregabalin (lyrica) 150 mg preoperative 1 hour before and the postoperative sham block will perform.

Drug: pregabalin (lyrica)

placebo group

PLACEBO COMPARATOR

a placebo capsule 1 hour before surgery and the postoperative sham block will perform.

Drug: Placebo oral tablet

adductor channel block group

ACTIVE COMPARATOR

A preoperative placebo capsule will be given.This group will receive postoperative adductor channel block including 10 mL of 0.25% bupivacaine with 5 μg/mL epinephrine

Drug: adductor canal block including bupivacaine

Interventions

pregabalin (lyrica) DRUG

preoperative pregabalin and the postoperative sham block will perform.

pregabalin (lyrica)

Placebo oral tablet DRUG

The preoperative placebo oral tablet and the postoperative sham block will perform.

placebo group

adductor canal block including bupivacaine DRUG

The preoperative placebo oral tablet and adductor channel block including 10 mL of 0.25% bupivacaine with 5 μg/mL epinephrine

adductor channel block group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients between the ages of 18 and 70 years
• American Society of Anesthesiologists I or II
• Scheduled to undergo knee arthroscopy

You may not qualify if:

• allergic to any medicines
• History of drug or alcohol abuse,
• Opioids or sedative medications
• History of psychiatric conditions
• Pregnant or lactating women

Sponsors & Collaborators

• Ankara Diskapi Training and Research Hospital: lead

Study Sites (1)

Diskapi Teaching and Research Hospital

Ankara, Altindag, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Pregabalin

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

gamma-Aminobutyric Acid; Aminobutyrates; Butyrates; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Amino Acids; Amino Acids, Peptides, and Proteins

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: specialist doctor

Study Record Dates

• First Submitted: March 26, 2018
• First Posted: May 21, 2018
• Study Start: June 1, 2018
• Primary Completion: October 1, 2018
• Study Completion: December 1, 2018
• Last Updated: October 18, 2019

Record last verified: 2019-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)