Response to Periodontal Therapy in a Chronic Kidney Disease Population

NCT03525457 | Unknown DMC

• 1 other identifier: 180104004
• Study Type: interventional
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate periodontal and systemic parameters of a cohort of chronic kidney disease (stage 5) patients, before and three months after non-surgical periodontal treatment. It does not consider a control group.

Conditions

Chronic Kidney Disease Stage 5; Periodontal Disease

Keywords

Glomerular filtration rate; Periodontitis; Chronic kidney disease

Outcome Measures

Primary Outcomes (1)

• Change in Clinical Attachment Level (CAL)

  Change from baseline CAL (in mm) at three months

  3 months

Secondary Outcomes (1)

• Change in Bleeding on probing (BOP)

  3 months

Study Arms (1)

Experimental

EXPERIMENTAL

Non surgical periodontal therapy

Procedure: Non Surgical Periodontal Therapy

Interventions

Non Surgical Periodontal Therapy PROCEDURE

Non Surgical Periodontal Therapy in 2 to 3 sessions

Experimental

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Chronic kidney disease patients in Stage 5 (candidates to renal transplant)

You may not qualify if:

• Younger than 18 year old.

Sponsors & Collaborators

• Pontificia Universidad Catolica de Chile: lead

Study Sites (1)

Clínica Odontológica Docente UC

Santiago, Santiago Metropolitan, Chile

RECRUITING

Related Publications (4)

• Almeida S, Figueredo CM, Lemos C, Bregman R, Fischer RG. Periodontal treatment in patients with chronic kidney disease: a pilot study. J Periodontal Res. 2017 Apr;52(2):262-267. doi: 10.1111/jre.12390. Epub 2016 May 2.

  PMID: 27135778 BACKGROUND

• Graziani F, Cei S, La Ferla F, Vano M, Gabriele M, Tonetti M. Effects of non-surgical periodontal therapy on the glomerular filtration rate of the kidney: an exploratory trial. J Clin Periodontol. 2010 Jul;37(7):638-43. doi: 10.1111/j.1600-051X.2010.01578.x. Epub 2010 May 25.

  PMID: 20500539 BACKGROUND

• Chambrone L, Foz AM, Guglielmetti MR, Pannuti CM, Artese HP, Feres M, Romito GA. Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate. J Clin Periodontol. 2013 May;40(5):443-56. doi: 10.1111/jcpe.12067. Epub 2013 Feb 21.

  PMID: 23432795 BACKGROUND

• Limeres J, Garcez JF, Marinho JS, Loureiro A, Diniz M, Diz P. Early tooth loss in end-stage renal disease patients on haemodialysis. Oral Dis. 2016 Sep;22(6):530-5. doi: 10.1111/odi.12486. Epub 2016 May 27.

  PMID: 27038430 BACKGROUND

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Periodontal Diseases; Periodontitis

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Maite C Souyet, MsC

  Pontificia Universidad Catolica de Chile

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Maite C Souyet, MsC

CONTACT

+56978786186; msouyet@gmail.com

Patricio F Smith, PhD

CONTACT

psmithf@uc.cl

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: DDS, MsC

Study Record Dates

• First Submitted: May 2, 2018
• First Posted: May 15, 2018
• Study Start: August 6, 2018
• Primary Completion: August 1, 2019
• Study Completion: December 1, 2019
• Last Updated: August 31, 2018

Record last verified: 2018-08

Locations

CL (1)