Microvascular Endothelial Function in a Cohort of Patients With the Cardiac Form of Chronic Chagas Disease.
1 other identifier
observational
70
1 country
1
Brief Summary
The present study aims to evaluate the microvascular endothelial function of a single centre cohort of patients with the cardiac form of Chagas disease, and to search for associations with clinical and laboratory variables.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Aug 2018
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 21, 2018
CompletedFirst Posted
Study publicly available on registry
May 15, 2018
CompletedStudy Start
First participant enrolled
August 20, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2020
CompletedAugust 20, 2020
August 1, 2020
2 years
April 21, 2018
August 19, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Endothelium-dependent skin microvascular function
systemic microvascular vasodilation induced by endothelium-dependent agents
2 hours
Secondary Outcomes (1)
Endothelium-dependent skin capillary density
1 hour
Study Arms (2)
patients presenting with Chagas cardiomyopathy
Evaluation of systemic microvascular reactivity using laser speckle contrast imaging Evaluation of skin capillary density using video-capillaroscopy
control group
Evaluation of systemic microvascular reactivity using laser speckle contrast imaging Evaluation of skin capillary density using video-capillaroscopy
Interventions
Evaluation of endothelial-dependent microvascular reactivity and capillary recruitment
Eligibility Criteria
The present study aims to evaluate the microvascular endothelial function of a single centre cohort of patients presenting with the cardiac form of Chagas disease in the National Institute of Cardiology, Ministry of Health, Rio de Janeiro,, Brazil
You may qualify if:
- patients presenting with Chagas cardiomyopathy
You may not qualify if:
- diabetes
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National Institute of Cardiology, Ministry of Health, Brazil
Rio de Janeiro, 22240-006, Brazil
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Senior Researcher, MD, PhD
Study Record Dates
First Submitted
April 21, 2018
First Posted
May 15, 2018
Study Start
August 20, 2018
Primary Completion
August 1, 2020
Study Completion
August 1, 2020
Last Updated
August 20, 2020
Record last verified: 2020-08