Left Ventricular Diastolic Function During Anesthesia Induction
Influence of Left Ventricular Diastolic Function on Hemodynamic Stability During Anesthesia Induction and on Postoperative Complications
1 other identifier
observational
200
1 country
1
Brief Summary
Diastolic dysfunction is an important cause of hemodynamic instability in the perioperative field.Therefore this study aims to investigate the influence of existing diastolic dysfunction or deterioration of diastolic function on hemodynamic stability during induction of anesthesia and postoperative complications. The impact of different anesthetics on diastolic function is investigated.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2017
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2017
CompletedFirst Submitted
Initial submission to the registry
April 30, 2018
CompletedFirst Posted
Study publicly available on registry
May 11, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 27, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
September 27, 2018
CompletedMarch 12, 2019
March 1, 2019
1.5 years
April 30, 2018
March 10, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Norepinephrine
Cumulative dose of norepinephrine (adjusted for body weight) during the first 30 minutes after induction of anesthesia
30 minutes after induction of anesthesia
Secondary Outcomes (2)
e'
Directly after induction of anesthesia
E / e'
Directly after induction of anesthesia
Study Arms (2)
Sevoflurane
Anesthesia maintenance
Propofol
Anesthesia maintenance
Interventions
Eligibility Criteria
All patients scheduled for surgery under general anesthesia
You may qualify if:
- Patients older than 60 years scheduled for general anesthesia
You may not qualify if:
- Mitral regurgitation or stenosis \> I°
- Sp. mitral valve repair or replacement
- Pericardial effusion
- Atrial fibrillation/flutter
- Patients with pacemaker
- BMI \> 35 kg/m2
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Universitätsklinikum Hamburg-Eppendorf
Hamburg, 20246, Germany
Related Publications (1)
Kahl U, Vens M, Pollok F, Menke M, Duckstein C, Gruetzmacher J, Schirren L, Yu Y, Fischer M, Zollner C, Goepfert MS, Roeher K. Do Elderly Patients With Diastolic Dysfunction Require Higher Doses of Norepinephrine During General Anesthesia for Noncardiac Surgeries? A Prospective Observational Study. Anesth Analg. 2021 Feb 1;132(2):420-429. doi: 10.1213/ANE.0000000000005304.
PMID: 33264119DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Katharina Roeher, Dr. med.
Universitätsklinikum Hamburg-Eppendorf
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 30, 2018
First Posted
May 11, 2018
Study Start
April 1, 2017
Primary Completion
September 27, 2018
Study Completion
September 27, 2018
Last Updated
March 12, 2019
Record last verified: 2019-03