Prevalence of Familial Hypercholesterolaemia (FH) in Italian Patients With Coronary Artery Disease
POSTER
1 other identifier
observational
5,415
1 country
81
Brief Summary
Evaluate the prevalence of familial hypercholesterolemia (FH) in patients with documented coronary artery disease (CAD) event \[acute myocardial infarction (AMI), acute coronary syndrome (ACS), coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI)\] followed by 100 cardiological centers representative of the whole Italian territory
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2016
81 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 15, 2016
CompletedFirst Submitted
Initial submission to the registry
April 13, 2018
CompletedFirst Posted
Study publicly available on registry
May 9, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 30, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
May 30, 2018
CompletedOctober 9, 2020
April 1, 2018
2 years
April 13, 2018
October 7, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Familial hypercholesterolemia diagnosis
Dutch Lipid Clinic Network Score (DLCNS) for FH The DLCNS is a validated set of criteria based on the patients family history of premature cardiovascular disease (CVD) in their first degree relatives, their own CVD history, their untreated lipid levels and physical signs such as the presence of tendon xanthomata or arcus cornealis prior to the age of 45. The subsequent score categorizes patients by the likelihood of Familial Hypercholesterolaemia (FH) diagnosis. Definite FH if score \>8 Probable FH if score 6-8 Possible FH if score 3-5 Unlikely FH if score \<3
Inclusion
Genetic examination
Sequencing of (LDLR, APOB, PVSK9 and LDLRAP1)
Inclusion
Eligibility Criteria
Patients must have a documented coronary artery disease, more precisely: ACS PCI CABG The index event must be occurred between 15 days and 8 weeks preceding the enrollment
You may qualify if:
- Patients must have a documented coronary artery disease, more precisely:
- ACS PCI CABG The index event must be occurred between 15 days and 8 weeks preceding the enrollment.
- \- Written informed consent to participate to the study
You may not qualify if:
- Patients unwilling to give their written informed consent.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Heart Care Foundationlead
- Fondazione SISAcollaborator
Study Sites (81)
Istituto Scientifico Inrca - Uo Cardiologia/Utic/Telecardiologia
Ancona, Italy
Ospedali Riuniti - Sod Cardiologia Ospedaliera Emod. E Utic
Ancona, Italy
Osp. Andria Canosa - Po Andria - Cardiologia - Utic
Andria, Italy
Ospedale Generale Regionale-Po U. Parini - U.O. Cardiologia E Cure Intensive Card.
Aosta, Italy
Ospedale Civile - U.O.C. Cardiologia
Arzignano, Italy
Ospedale Gen.Le Prov.Le C.G. Mazzoni - Sc Cardiologia
Ascoli Piceno, Italy
Ospedale E. Muscatello - U.O. Di Cardiologia - Utic
Augusta, Italy
Presidio Ospedaliero Moscati - U.O.C. Cardiologia
Aversa, Italy
Ospedale Policlinico - U.O. Cardiologia Universitaria
Bari, Italy
Ospedale San Paolo - Cardiologia-Utic
Bari, Italy
Azienda Ospedaliera G. Rummo - Cardiologia Interventistica E Utic
Benevento, Italy
Ospedale Maggiore - U.O. Di Cardiologia
Bologna, Italy
Ospedale Generale Regionale - Ospedale Generale Regionale Divisione Di Cardiologia
Bolzano, Italy
Ospedale Ss. Trinita' - S.C. Di Cardiologia
Borgomanero, Italy
Azienda Ospedaliera G. Brotzu - Struttura Complessa Di Cardiologia
Cagliari, Italy
Ospedale San Giovanni Di Dio - Clinica Cardiologica
Cagliari, Italy
Ospedale A. Cardarelli - U.O. Cardiologia E Utic
Campobasso, Italy
Presidio Ospedaliero F. Ferrari - Cardiologia - Utic
Casarano, Italy
Az. Ospedaliera S. Anna E S. Sebastiano - U.O. Cardiologia-Utic
Caserta, Italy
P.O. Garibaldi-Nesima - U.O.C. Di Cardiologia
Catania, Italy
Fondazione G. Giglio - U.O. Cardiologia E Utic
Cefalù, Italy
Ospedale Bassini - U.O. Cardiologia E Utic
Cinisello Balsamo, Italy
Ospedale Di Cittadella - U.O. Cardiologia
Cittadella, Italy
Ospedale San Giuseppe Da Copertino - U.O. Di Cardiologia-Utic
Copertino, Italy
Ospedale Valdichiana Santa Margherita - Uos Cardiologia E Hdu
Cortona, Italy
Maria Cecilia Hospital - U.O. Di Cardiologia
Cotignola, Italy
Ospedale Di Cremona - Uo Di Cardiologia
Cremona, Italy
Ospedale Civile Sant'Antonio Abate - U.O.C. Di Cardiologia E Utic
Erice, Italy
Ospedale Civile - U.O.C. Cardiologia - Utic
Fidenza, Italy
Aou Careggi - Interventistica Cardiologica Strutturale
Florence, Italy
Aou Careggi - Riabilitazione Cardiologica
Florence, Italy
Ospedale Santa Maria Nuova - Hdu Cardiologica/Utic
Florence, Italy
Ospedali Riuniti - S.C. Di Cardiologia Univ.-Utic
Foggia, Italy
Ospedale G.B. Morgagni - L. Pierantoni - U.O. Cardiologia
Forlì, Italy
E.O. Ospedali Galliera - S. C. Cardiologia
Genova, Italy
Ospedale Civile - Sc Cardiologia Area Nord
Guastalla, Italy
Citta' Di Lecce Hospital - U.O. Di Cardiologia
Lecce, Italy
Nuovo Ospedale Versilia - Sc Cardiologia
Lido di Camaiore, Italy
Ospedale Civile M. Giannuzzi - Cardiologia E Utic
Manduria, Italy
Presidio Ospedaliero Paolo Borsellino - U.O.C Cardiologia- Utic
Marsala, Italy
Ospedale G. Fucito - U.O. Di Cardiologia E Utic
Mercato San Severino, Italy
Policlinico Di Monza - Uo Cardiol. Clinica E Scompenso Cardiaco
Monza, Italy
Aorn Cardarelli - U.O. Cardiologia Con Utic
Napoli, Italy
Aorn Osp. Dei Colli- Po Vincenzo Monaldi - U.O.C. Cardiologia - S.U.N.
Napoli, Italy
Aou Maggiore Della Carita' - Cardiologia Ii
Novara, Italy
Ospedale San Francesco - Cardiologia - Utic
Nuoro, Italy
Ospedale San Luigi Gonzaga - S.C.D.O. Cardiologia
Orbassano, Italy
Maria Eleonora Hospital - Cardiologia
Palermo, Italy
Ospedale Civico - U.O. Cardiologia
Partinico, Italy
Centro Cuore Morgagni - U.F. Utic Ed Emodinamica
Pedara, Italy
Ospedale Civile Ave Gratia Plena - U.O. Di Cardiologia E Utic
Piedimonte Matese, Italy
Ospedale San Jacopo - U.O. Cardiologia
Pistoia, Italy
Policlinico Citta' Di Pomezia S. Anna - U.O. Cardiologia-Utic
Pomezia, Italy
Ospedale Santa Maria Delle Grazie - U.O. Cardiologia - Utic
Pozzuoli, Italy
Arcispedale Santa Maria Nuova - S.C. Cardiologia
Reggio Emilia, Italy
Ospedale Infermi - U.O. Cardiologia
Rimini, Italy
Campus Biomedico - Cardiologia
Roma, Italy
Ospedale Madre Giuseppina Vannini - U.O.C. Cardiologia
Roma, Italy
P.O. San Filippo Neri - Asl Roma 1 - Uoc Cardiologia E Utic
Roma, Italy
Policlinico Casilino - U.O. Cardiologia
Roma, Italy
Policlinico Umberto Primo - Cardiologia B - Cardiologia E Angiologia
Roma, Italy
A.O.U.S. Giovanni Di Dio-Ruggi D'Aragona - Sc Di Cardiologia
Salerno, Italy
Ospedale G. Fracastoro - U.O.C. Di Cardiologia
San Bonifacio, Italy
Ospedale Casa Sollievo Della Sofferenza - Cardiologia - Utic - Riabil Cardiologica
San Giovanni Rotondo, Italy
Presidio Ospedaliero - U.O. Cardiologia
Sanremo, Italy
Ospedale San Giuseppe E Melorio - U.O.C. Cardiologia Utic
Santa Maria Capua Vetere, Italy
Presidio Ospedaliero Di Saronno - U.O.C. Di Cardiologia
Saronno, Italy
Ospedale Ignazio Veris Delli Ponti - Uoc Cardiologia-Utic
Scorrano, Italy
IRCCS Policlinico Multimedica - UO Cardiologia
Sesto San Giovanni, Italy
Ospedale San Matteo Degli Infermi - Servizio Di Cardiologia Con Utic
Spoleto, Italy
Ospedale Umberto I - Uoc Cardiologia E Utic
Syracuse, Italy
Casa Di Cura Villa Verde - Cardiologia
Taranto, Italy
Ospedale San Timoteo - Ssd Cardiologia Emodinamica
Termoli, Italy
Centro Polifunzionale Boldrini - Cardiologia Riabilitativa-Cardioaction
Thiene, Italy
Aou Citta' Della Salute E Della Scienza-Scdu Cardiologia
Torino, Italy
Ospedali Treviglio-Caravaggio - Cardiologia
Treviglio, Italy
Ospedali Riuniti - Osp. Maggiore - A.F. Cardiologia E Riabilitazione Cardio
Trieste, Italy
Pou Santa Maria Della Misericordia - S.O.C. Cardiologia
Udine, Italy
Ospedale Di Circolo E Fondazione Macchi - Ssd Unita' Di Cure Intensive Coronariche
Varese, Italy
Ospedale San Pio Da Pietrelcina - Cardiologia
Vasto, Italy
Ics Maugeri Spa Societa' Benefit - Uo Cardiologia Riabilitativa
Veruno, Italy
Related Publications (2)
Gulizia MM, Maggioni AP, Abrignani MG, Bilato C, Mangiacapra F, Sanchez FA, Piovaccari G, Montagna L, Marini M, De Biasio M, Averna M, Casula M, Colivicchi F, Fabbri G, Lucci D, Zampoleri V, Catapano AL; POSTER Investigators. Prevalence Of familial hypercholeSTerolaemia (FH) in Italian Patients with coronary artERy disease: The POSTER study. Atherosclerosis. 2020 Sep;308:32-38. doi: 10.1016/j.atherosclerosis.2020.07.007. Epub 2020 Jul 29.
PMID: 32823190RESULTQureshi N, Da Silva MLR, Abdul-Hamid H, Weng SF, Kai J, Leonardi-Bee J. Strategies for screening for familial hypercholesterolaemia in primary care and other community settings. Cochrane Database Syst Rev. 2021 Oct 7;10(10):CD012985. doi: 10.1002/14651858.CD012985.pub2.
PMID: 34617591DERIVED
Biospecimen
Full gene sequencing of the genes involved in FH (LDLR, APOB, PVSK9 and LDLRAP1)
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 13, 2018
First Posted
May 9, 2018
Study Start
June 15, 2016
Primary Completion
May 30, 2018
Study Completion
May 30, 2018
Last Updated
October 9, 2020
Record last verified: 2018-04
Data Sharing
- IPD Sharing
- Will not share