Behavioral Economic Analysis of Demand for Marijuana

NCT03518567 | Completed Phase 2 Results FDA Drug

• 1 other identifier: #1502001185
• Study Type: interventional
• Target: 133
• Locations: 1 country
• Sites: 1

Brief Summary

This laboratory study will employ a multi-session experimental design to examine the behavioral economic demand for marijuana, by studying effect of marijuana administration (High THC) on demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly.

Conditions

Marijuana Smoking

Outcome Measures

Primary Outcomes (1)

• Validity of the Marijuana Purchase Task (MPT)

  The Marijuana Purchase Task will be used to collect data on marijuana demand. Participants indicate how much marijuana they would purchase at varying levels of price (e.g., free - $60). Indices of marijuana demand are derived from the task and used to determine the relative value of marijuana for each participant. Hits purchased on the MPT will correspond with actual number of hits purchased and smoked in the laboratory. Primary outcome is percentage of participants who purchased and smoked exactly what they said they would.

  Duration of the experimental session (i.e., 60 minutes)

Secondary Outcomes (2)

• Change in Marijuana Craving Questionnaire (MCQ)

  The MCQ will be administered pre- and post- marijuana smoking during the experimental session, up to 6 hours

• Marijuana Smoking Topography

  Marijuana smoking topography indices will be collected during the 1-hour ad libitum marijuana smoking topography experimental session.

Study Arms (1)

High THC dose (6% THC)

EXPERIMENTAL

Smoked marijuana cigarettes (High THC dose \[6% THC\])

Drug: Smoked marijuana cigarettes: High THC dose (6% THC)

Interventions

Smoked marijuana cigarettes: High THC dose (6% THC) DRUG

Smoked marijuana cigarettes (High THC dose \[6% THC\])

High THC dose (6% THC)

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• marijuana use at least 8 times in the past month on average and at least monthly for the past 6 months
• English-speaking
• negative urine toxicology screen for drugs other than marijuana
• non-treatment seeking
• purchase of marijuana at least twice in the past 6 months to confirm familiarity with the construct to be measured

You may not qualify if:

• positive pregnancy test
• nursing
• inability to use contraception during the study
• poor physical health
• positive breath alcohol concentration
• diagnosis of a current affective disorder, psychosis, and panic disorder
• self-report of past serious adverse reaction to marijuana
• current psychotropic drug use
• smoking more than 20 tobacco cigarettes per day
• inability to abstain from marijuana for 15 hours
• body mass index outside 18.5-30 kg/m2 range

Sponsors & Collaborators

• Brown University: lead

Study Sites (1)

Brown University

Providence, Rhode Island, 02903, United States

Location

MeSH Terms

Conditions

Marijuana Smoking

Interventions

Dronabinol

Condition Hierarchy (Ancestors)

Marijuana Use; Behavior; Smoking, Non-Tobacco Products; Smoking

Intervention Hierarchy (Ancestors)

Cannabinoids; Terpenes; Hydrocarbons; Organic Chemicals

Results Point of Contact

• Title: Elizabeth Aston, PhD
• Organization: Brown University

elizabeth_aston@brown.edu

401-863-6668

Study Officials

• Elizabeth Aston, PhD

  Brown University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 9, 2018
• First Posted: May 8, 2018
• Study Start: October 15, 2018
• Primary Completion: May 24, 2021
• Study Completion: May 24, 2021
• Last Updated: February 12, 2024
• Results First Posted: February 12, 2024

Record last verified: 2024-02

Locations

US (1)