NCT03516474

Brief Summary

In this study the investigators are testing a device that may help us tell how well the participants' wound is healing. This device is called the MIMOSA, and it shines different "colours" of light on the participants' skin. It will not touch the participants' skin, or change how the participants' wound is healing. The MIMOSA is designed to be used alongside the camera that is built into the participants' cell phone, and the investigators will use a cell phone to take a picture of the participants' skin. This picture will tell us how much oxygen is getting to the participants' wound, which can tell us more about how the participants are healing. The MIMOSA device is an experimental diagnostic tool, and will not influence how the participants' wound is healing.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
400

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started May 2018

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 8, 2018

Completed
2 months until next milestone

First Posted

Study publicly available on registry

May 4, 2018

Completed
11 days until next milestone

Study Start

First participant enrolled

May 15, 2018

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2019

Completed
Last Updated

May 4, 2018

Status Verified

April 1, 2018

Enrollment Period

1.6 years

First QC Date

March 8, 2018

Last Update Submit

May 3, 2018

Conditions

Keywords

nirdiabetesdiabetic foot ulcer (DFU).wound

Outcome Measures

Primary Outcomes (1)

  • Lower rates of DFU recurrence in patients monitored using mHealth

    Accurately recorded pictures and information will help clinicians to accurately access patient foot health and hopefully reduce the frequency of DFU's using this information.

    0-12 months

Study Arms (4)

St. Michael's Hospital

St. Michael's Hospital is an Acute care centre for the diabetic lower extremity. n=100

Device: MIMOSA Diagnostics

South Riverdale Community Health Centre

South Riverdale is a Community Health Centre focused on prevention. n=100

Device: MIMOSA Diagnostics

Westpark

Westpark is a rehabilitation site focused on post-operative/amputation care and preservation of the opposite limb. n=100

Device: MIMOSA Diagnostics

Women's College Hospital

Women's College Hospital is an outpatient wound clinic focused on the management of DFUs. n=100

Device: MIMOSA Diagnostics

Interventions

The MIMOSA shines different "colours" of light on your skin. It will not touch your skin, or change how your wound is healing. The MIMOSA is designed to be used alongside the camera that is built into your cell phone, and we will use a cell phone to take a picture of your skin. This picture will tell us how much oxygen is getting to your wound, which can tell us more about how you are healing. The MIMOSA device is an experimental diagnostic tool, and will not influence how your wound is healing.

Also known as: MIMOSA
South Riverdale Community Health CentreSt. Michael's HospitalWestparkWomen's College Hospital

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Adult diabetic subjects will be identified as candidates for our study if they present to the outpatient clinic, emergency department, inpatient or wound care team with or without a DFU. A subject is considered a patient with a DFU on one foot. If the patient has 2 wounds on the same foot, they are still considered one subject and both wounds are imaged. If the subject has a wound on the opposite foot they are considered a new subject.

You may qualify if:

  • Diabetes: Type I or Type II.
  • Outpatient or inpatient
  • Diabetic Foot Ulcer
  • Adhere to monitoring schedule

You may not qualify if:

  • Presence of invasive infection requiring intravenous antibiotics
  • Cognitively able to give consent \& participate in study
  • Active malignancy
  • End stage renal disease
  • Patients who are participating in another clinical study for ulcer management
  • Patients with a known history of poor compliance with medical treatment
  • Patients who are unable to understand the aims of the study and not give informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (5)

  • Pelletier C, Dai S, Roberts KC, Bienek A, Onysko J, Pelletier L. Report summary. Diabetes in Canada: facts and figures from a public health perspective. Chronic Dis Inj Can. 2012 Dec;33(1):53-4.

    PMID: 23294922BACKGROUND
  • Skrepnek GH, Mills JL Sr, Armstrong DG. A Diabetic Emergency One Million Feet Long: Disparities and Burdens of Illness among Diabetic Foot Ulcer Cases within Emergency Departments in the United States, 2006-2010. PLoS One. 2015 Aug 6;10(8):e0134914. doi: 10.1371/journal.pone.0134914. eCollection 2015.

    PMID: 26248037BACKGROUND
  • Serrano V, Spencer-Bonilla G, Boehmer KR, Montori VM. Minimally Disruptive Medicine for Patients with Diabetes. Curr Diab Rep. 2017 Sep 23;17(11):104. doi: 10.1007/s11892-017-0935-7.

    PMID: 28942581BACKGROUND
  • Cross KM, Leonardi L, Payette JR, Gomez M, Levasseur MA, Schattka BJ, Sowa MG, Fish JS. Clinical utilization of near-infrared spectroscopy devices for burn depth assessment. Wound Repair Regen. 2007 May-Jun;15(3):332-40. doi: 10.1111/j.1524-475X.2007.00235.x.

    PMID: 17537120BACKGROUND
  • Vashist SK, Schneider EM, Luong JH. Commercial Smartphone-Based Devices and Smart Applications for Personalized Healthcare Monitoring and Management. Diagnostics (Basel). 2014 Aug 18;4(3):104-28. doi: 10.3390/diagnostics4030104.

    PMID: 26852680BACKGROUND

MeSH Terms

Conditions

Diabetic FootDiabetes MellitusWounds and Injuries

Condition Hierarchy (Ancestors)

Diabetic AngiopathiesVascular DiseasesCardiovascular DiseasesFoot UlcerLeg UlcerSkin UlcerSkin DiseasesSkin and Connective Tissue DiseasesDiabetes ComplicationsEndocrine System DiseasesDiabetic NeuropathiesGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic Diseases

Central Study Contacts

Karen Cross, MD, PhD

CONTACT

Julie Perry, MSc, PhD

CONTACT

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 8, 2018

First Posted

May 4, 2018

Study Start

May 15, 2018

Primary Completion

December 31, 2019

Study Completion

December 31, 2019

Last Updated

May 4, 2018

Record last verified: 2018-04

Data Sharing

IPD Sharing
Will not share

All personal health information given will be anonymized when it is collected: a master linking log will link potentially identifiable characteristics to a specific study ID number listed in the app, to be held only by the Principal Investigator under lock or encryption and password protection. Study data seen by research assistants and data analysts will be strictly anonymized, encrypted, password protected, and stored in a locked research lab, separately from the master linking log.