NCT03515473

Brief Summary

Background The authors' aim was to compare the influence of various electrode designs on selected objective and subjective clinical outcomes for cochlear implant recipients using the same model of receiver-stimulator, Cochlear™ Nucleus® Profile Series and sound processor. Methods A multicenter study with subjects with profound sensorineural hearing loss, who were implanted and followed up in two tertiary centers. A total of 54 ears were implanted with Cochlear™ Nucleus® CI532, 51 with Cochlear™ Nucleus® CI522 and 54 with the Cochlear™ Nucleus® CI512. Implant loss and intraoperative electrophysiological tests (electrically evoked stapedial reflex threshold \[ESRT\], neural response telemetry threshold \[T-NRT\] and impedance), postoperative data (C-level, T-level, dynamic range, T-NRT and power consumption) and intracochlear position of the active electrode were analyzed with Nucleus Custom Sound 4.4 software.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
139

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Nov 2015

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 13, 2015

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 4, 2017

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2017

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

January 15, 2018

Completed
4 months until next milestone

First Posted

Study publicly available on registry

May 3, 2018

Completed
Last Updated

May 3, 2018

Status Verified

May 1, 2018

Enrollment Period

1.6 years

First QC Date

January 15, 2018

Last Update Submit

May 2, 2018

Conditions

Keywords

cochlear implantCI532CI512CI522electrode arrayperimodiolarelectrophysiology

Outcome Measures

Primary Outcomes (3)

  • Intraoperative measurements

    Intraoperative impedance (kOhm) of the stimulating electrode with different types of cochlear implants.

    1 day

  • Intraoperative measurements

    Electrical stapedial reflex threshold (ESRT; current unit) with different types of cochlear implants

    1 day

  • Intraoperative measurements

    Neural response telemetry threshold (T-NRT; current unit) with different types of cochlear implants

    1 day

Secondary Outcomes (3)

  • Postoperative measurements

    3 months

  • Postoperative measurements

    3 months

  • Postoperative measurements

    3 months

Study Arms (3)

CI532

Patients with CI532 cochlear implant

Device: cochlear implant

CI522

Patients with CI522 cochlear implant

Device: cochlear implant

CI512

Patients with CI512 cochlear implant

Device: cochlear implant

Interventions

cochlear implant surgery

CI512CI522CI532

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Subjects implanted with CI532 or CI512 or CI522 in Szeged and St. Pölten between the indicated time frames

You may qualify if:

  • successful cochlear implantation with CI532 or CI512 or CI522
  • gave informed consent

You may not qualify if:

  • unsuccessful cochlear implantation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Universitiy of Szeged, Department of Otorhinolaryngology, Head and Neck Surgery

Szeged, 6725, Hungary

Location

MeSH Terms

Interventions

Cochlear Implants

Intervention Hierarchy (Ancestors)

Neural ProsthesesImplantable NeurostimulatorsElectrodes, ImplantedElectrodesElectrical Equipment and SuppliesEquipment and SuppliesProstheses and ImplantsHearing AidsSensory Aids

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor Head of Otorhinolaryngology Clinic

Study Record Dates

First Submitted

January 15, 2018

First Posted

May 3, 2018

Study Start

November 13, 2015

Primary Completion

June 4, 2017

Study Completion

November 30, 2017

Last Updated

May 3, 2018

Record last verified: 2018-05

Data Sharing

IPD Sharing
Will not share

Locations