NCT03509493

Brief Summary

FibriCheck is a Conformité Européenne (CE)-approved (class IIa) medically diagnostic application that allows for heart rhythm registrations based on an optical signal captured via the smartphone camera. FibriCheck is only available on prescription causing the physician to stay in the 'driving seat' and the application distribution to be traced. By using FibriCheck, a medically validated smartphone application, daily rhythm measurements can be performed using only the smartphone of the patient. This allows for the heart rhythm to be registered and monitored in a home environment and the data to be automatically sent to the physician. This enables the implementation of FibriCheck in two types of scenarios:

  • Scenario 1: the follow-up of patients with high risk parameters for AF development for primary and secondary prevention, whereby detection of AF will result in therapeutic intervention
  • Scenario 2: the realisation of monitoring of the heart rhythm of patients post intervention in a home environment

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
465

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jun 2017

Shorter than P25 for all trials

Geographic Reach
1 country

8 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2017

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2017

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

April 24, 2018

Completed
2 days until next milestone

First Posted

Study publicly available on registry

April 26, 2018

Completed
Last Updated

April 30, 2018

Status Verified

April 1, 2018

Enrollment Period

7 months

First QC Date

April 24, 2018

Last Update Submit

April 26, 2018

Conditions

Keywords

Primary preventionSecondary preventionClinical practice

Outcome Measures

Primary Outcomes (1)

  • Detection of unknown atrial fibrillation

    31 December 2017

Secondary Outcomes (1)

  • Detection of recurrent atrial fibrillation

    31 December 2017

Study Arms (6)

Patients without structural heart disease

Diagnostic Test: FibriCheck

Patients with structural heart disease

Diagnostic Test: FibriCheck

Patients with high risk parameters for AF development

Diagnostic Test: FibriCheck

Patients post-cryptogenic stroke

Diagnostic Test: FibriCheck

Patients post-cardioversion therapy

Diagnostic Test: FibriCheck

Patients post-ablation therapy

Diagnostic Test: FibriCheck

Interventions

FibriCheckDIAGNOSTIC_TEST

Digital health application

Patients post-ablation therapyPatients post-cardioversion therapyPatients post-cryptogenic strokePatients with high risk parameters for AF developmentPatients with structural heart diseasePatients without structural heart disease

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All eligible patients are included in the corresponding group

You may qualify if:

  • Group 1: Patients without structural heart disease
  • Age 65 and older
  • CHADSVASc score of 2 or more (including congestive heart failure, hypertension, age, diabetes, previous stroke, vascular disease and sex)
  • Comorbidities such as: coronary artery disease, kidney insufficiency, sleep apnea or symptomatic complaints with negative Holter in the past
  • Group 2: Patients with structural heart disease
  • Age 65 and older
  • CHADSVASc score of 2 or more
  • Left atrial volume indexed for body surface area (BSA) of 34 ml/m² or more, or left atrial diameter \> 5 cm
  • And any of the following indicators:
  • Diastolic dysfunction of at least grade 2 with restrictive filling (E/A 2 or more) or disturbed relaxation (E/A 0.8) and with E/e' septal 15 or more (E/e' lateral 10 or more) or tricuspid insufficiency (TI) of 2.8 m/s or more
  • At least mitral insufficiency (grade 2/3 or 3/3) or mitral stenosis
  • Hypertrophic (obstructive) cardiomyopathy
  • Group 3: Patients with high risk parameters for AF development
  • Age 65 or more
  • General Medical Record in the participating practice
  • +11 more criteria

You may not qualify if:

  • Non-native Dutch
  • Pacemaker dependent heart rhythm
  • Perniosis patient
  • Intense callus formation
  • Low adherence to protocol
  • Tremor or Parkinson
  • Signs of Alzheimer or dementia
  • No self-care ability
  • Known AF patient

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (8)

Ziekenhuis Oost Limburg

Genk, Limburg, 3600, Belgium

Location

Jessa Ziekenhuis

Hasselt, Limburg, 3500, Belgium

Location

AZ Maria Middelares

Ghent, Oost-Vlaanderen, 9000, Belgium

Location

AC Huisartsengeneeskunde KU Leuven

Leuven, Vlaams-Brabant, 3000, Belgium

Location

HAK Hooglede

Hooglede, West-Vlaanderen, 8830, Belgium

Location

Jan Yperman Ziekenhuis

Ieper, West-Vlaanderen, 8900, Belgium

Location

AZ Groeninge

Kortrijk, West-Vlaanderen, 8500, Belgium

Location

AZ Delta Ziekenhuis

Roeselare, West-Vlaanderen, 8800, Belgium

Location

Related Publications (1)

  • Beerten SG, Proesmans T, Vaes B. A Heart Rate Monitoring App (FibriCheck) for Atrial Fibrillation in General Practice: Pilot Usability Study. JMIR Form Res. 2021 Apr 7;5(4):e24461. doi: 10.2196/24461.

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 24, 2018

First Posted

April 26, 2018

Study Start

June 1, 2017

Primary Completion

December 31, 2017

Study Completion

December 31, 2017

Last Updated

April 30, 2018

Record last verified: 2018-04

Locations