Chinese EOPD Registry

NCT03508960 | Recruiting

• 1 other identifier: CEOPDR
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the Chinese Early-onst Parkinson's disease Registry (CEOPDR) is to develop a database of persons with early-onset Parkinson's disease (EOPD) in China.

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (3)

• Database of Early-onset Parkinson's Disease

  To collect 3000 patients with early-onset parkinson's disease and establish the database of early-onset Parkinson's disease in mainland China.

  10 years

• Risk Factors

  To characterize clinical feature and environmental factors among Chinese early-onset parkinson's disease

  10 years

• Genetic Basis

  To characterize the genetic basis of Chinese EOPD and detect clinically relevant genetic variants in these cases.

  10 years

Eligibility Criteria

• Age: Up to 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

PD patients with early-onset

You may qualify if:

• Patients diagnosed with PD by UKBB and other standard criteria Age of onset is no more than 50 years old.

You may not qualify if:

• Patients have a family history of PD.

Sponsors & Collaborators

• Xiangya Hospital of Central South University: lead

Study Sites (1)

Xiangya Hospital of Central South University

Changsha, Hunan, 410000, China

RECRUITING

Related Publications (5)

• Yang Y, Tang BS, Weng L, Li N, Shen L, Wang J, Zuo CT, Yan XX, Xia K, Guo JF. Genetic Identification Is Critical for the Diagnosis of Parkinsonism: A Chinese Pedigree with Early Onset of Parkinsonism. PLoS One. 2015 Aug 21;10(8):e0136245. doi: 10.1371/journal.pone.0136245. eCollection 2015.

  PMID: 26295349 BACKGROUND

• Liu ZH, Guo JF, Li K, Wang YQ, Kang JF, Wei Y, Sun QY, Xu Q, Wang DL, Xia K, Yan XX, Xu CS, Tang BS. Analysis of several loci from genome-wide association studies in Parkinson's disease in mainland China. Neurosci Lett. 2015 Feb 5;587:68-71. doi: 10.1016/j.neulet.2014.12.027. Epub 2014 Dec 17.

  PMID: 25528405 BACKGROUND

• Li K, Tang BS, Liu ZH, Kang JF, Zhang Y, Shen L, Li N, Yan XX, Xia K, Guo JF. LRRK2 A419V variant is a risk factor for Parkinson's disease in Asian population. Neurobiol Aging. 2015 Oct;36(10):2908.e11-5. doi: 10.1016/j.neurobiolaging.2015.07.012. Epub 2015 Jul 11.

  PMID: 26234753 BACKGROUND

• Liu Z, Tang B, Guo J, Zhou X, Sun Q, Xu Q, Xu C, Yan X. Mutations analysis of RAB39B gene in Chinese early-onset Parkinson's disease. Parkinsonism Relat Disord. 2016 Jul;28:157-8. doi: 10.1016/j.parkreldis.2016.03.019. Epub 2016 Mar 24. No abstract available.

  PMID: 27036214 RESULT

• Fan K, Tang BS, Wang YQ, Kang JF, Li K, Liu ZH, Sun QY, Xu Q, Yan XX, Guo JF. The GBA, DYRK1A and MS4A6A polymorphisms influence the age at onset of Chinese Parkinson patients. Neurosci Lett. 2016 May 16;621:133-136. doi: 10.1016/j.neulet.2016.04.014. Epub 2016 Apr 13.

  PMID: 27085534 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

extraction of DNA from peripheral blood

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Central Study Contacts

J Guo, Ph.D.

CONTACT

+8613974936815; guojifeng2003@163.com

Beisha Tang, Ph.D.

CONTACT

+8613974856709; bstang7398@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 11, 2018
• First Posted: April 26, 2018
• Study Start: February 1, 2017
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: May 11, 2018

Record last verified: 2018-04

Locations

CN (1)