NCT03507309

Brief Summary

The National Institute for Health Research (NIHR) Cardiovascular Health Informatics Collaborative is an observational, multi-centre and longitudinal study of clinical data from collaborating hospitals. A dataset of the longitudinal record for patients who presented with a suspected acute coronary syndrome, characterised by the request of a troponin test, has been developed (NHIC-Troponin Study).

Trial Health

83
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
257,948

participants targeted

Target at P75+ for all trials

Timeline
23mo left

Started Jan 2016

Longer than P75 for all trials

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress85%
Jan 2016Mar 2028

Study Start

First participant enrolled

January 1, 2016

Completed
2.1 years until next milestone

First Submitted

Initial submission to the registry

February 23, 2018

Completed
2 months until next milestone

First Posted

Study publicly available on registry

April 25, 2018

Completed
6.5 years until next milestone

Results Posted

Study results publicly available

October 8, 2024

Completed
3.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2028

Last Updated

October 8, 2024

Status Verified

July 1, 2024

Enrollment Period

12.3 years

First QC Date

February 23, 2018

Results QC Date

March 15, 2023

Last Update Submit

July 5, 2024

Conditions

TroponinAgeMortalityAcute Coronary Syndrome

Outcome Measures

Primary Outcomes (1)

  • Mortality, All-cause

    Number of patients who died (from any cause) including in-hospital, short-term and long-term mortality

    Hospital admission to 3 years follow-up

Secondary Outcomes (1)

  • Acute Revascularisation

    3 months follow-up

Study Arms (1)

Unselected cohort of patients who had a troponin measured

Patients who presented to hospital during the study period (2010-17) and had at least one troponin blood test measured.

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All patients with electronic records at collaborating hospitals.

You may qualify if:

  • All patients presenting to one of the collaborating hospitals.

You may not qualify if:

  • Nil

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (3)

  • Scott JK, Johnson T, Caskey FJ, Bailey P, Selman LE, Mulla A, Glampson B, Davies J, Papdimitriou D, Woods K, O'Gallagher K, Williams B, Asselbergs FW, Mayer EK, Lee R, Herbert C, Grant SW, Curzen N, Squire I, Kharbanda R, Shah A, Perera D, Patel RS, Channon K, Mayet J, Kaura A, Ben-Shlomo Y. Association between kidney function, frailty and receipt of invasive management after acute coronary syndrome. Open Heart. 2024 Oct 9;11(2):e002875. doi: 10.1136/openhrt-2024-002875.

    PMID: 39384342DERIVED

  • Kaura A, Hartley A, Panoulas V, Glampson B, Shah ASV, Davies J, Mulla A, Woods K, Omigie J, Shah AD, Thursz MR, Elliott P, Hemmingway H, Williams B, Asselbergs FW, O'Sullivan M, Lord GM, Trickey A, Sterne JA, Haskard DO, Melikian N, Francis DP, Koenig W, Shah AM, Kharbanda R, Perera D, Patel RS, Channon KM, Mayet J, Khamis R. Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study. PLoS Med. 2022 Feb 22;19(2):e1003911. doi: 10.1371/journal.pmed.1003911. eCollection 2022 Feb.

    PMID: 35192610DERIVED

  • Kaura A, Panoulas V, Glampson B, Davies J, Mulla A, Woods K, Omigie J, Shah AD, Channon KM, Weber JN, Thursz MR, Elliott P, Hemingway H, Williams B, Asselbergs FW, O'Sullivan M, Kharbanda R, Lord GM, Melikian N, Patel RS, Perera D, Shah AM, Francis DP, Mayet J. Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres. BMJ. 2019 Nov 20;367:l6055. doi: 10.1136/bmj.l6055.

    PMID: 31748235DERIVED

Related Links

MeSH Terms

Conditions

Acute Coronary Syndrome

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular Diseases

Results Point of Contact

Title
Dr Amit Kaura
Organization
Imperial College Healthcare NHS Trust
amit.kaura@nhs.net
020 3312 6666

Study Officials

  • Jamil Mayet

    Imperial College London

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
10 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Cardiology

Study Record Dates

First Submitted

February 23, 2018

First Posted

April 25, 2018

Study Start

January 1, 2016

Primary Completion (Estimated)

March 31, 2028

Study Completion (Estimated)

March 31, 2028

Last Updated

October 8, 2024

Results First Posted

October 8, 2024

Record last verified: 2024-07

Data Sharing

IPD Sharing
Will share

De-identified individual electronic patient record data for all primary and secondary outcome measures will be made available.

Shared Documents
STUDY PROTOCOL, SAP, CSR, ANALYTIC CODE
Time Frame
Data will me made available from study completion date.
Access Criteria
Data access requests will be reviewed by a Steering Committee from the participating Biomedical Research Centres. Requesters will be required to sign a Data Access Agreement.