Sponsor study identifier
Secondary identifiers
observational
9
1 country
8
Study Start
March 20, 2018
Actual (reported)Primary Completion
October 23, 2019
Actual (reported)Study Completion
October 23, 2019
Actual (reported)Background: PANS is an illness that comes on suddenly in children. The full name is Pediatric Acute-Onset Neuropsychiatric Syndrome. It can cause sudden obsessive-compulsive behaviors. It can also cause children to suddenly restricte their food intake. Researchers want to learn more about children with PANS. They also want to learn more about the illness. Objective: To study some disorders of behavior and emotion that start in childhood. Eligibility: Children 3 14 years old who have had severe obsessive-compulsive symptoms or food restriction start quickly Design: Parents will answer questions. The topics include: Their child s medical history Their child s physical and mental health Their family history. The focus will be on neurodevelopmental and psychiatric conditions. A family tree will be drawn. Participants will have a physical exam. Participants may take tests on paper or computer. These will focus on thinking, memory, and behavior. Participants and parents will give a blood sample. Participants will have magnetic resonance imaging (MRI). A strong magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides in and out of a metal scanner. Participants may have photos or videos taken. Participants may have other tests. These may include heart tests, sleep tests, and lumbar puncture. Sponsoring Institute: National Institute of Mental Health
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 23, 2019
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 20, 2018
Actual (reported)April 24, 2018
Actual (reported)April 25, 2018
Actual (reported)October 23, 2019
Actual (reported)October 23, 2019
Actual (reported)Establish national database and samples repository for pediatric acute-onset neuropsychiatric syndrome (PANS)
Study Completion
Identify unique and distinctive features of subgroups of patients with PANS, in order to determine the shared disease mechanism
Study completion
Elucidate the role of immune dysfunction in the syndrome of PANS, as well as for subgroups of patients
Study completion
Determine role of environmental pathogens, such as Group A streptococci, in the etiopathogenesis of PANS
Study completion
Investigate factors influencing host susceptibility and resistance
Study completion
Children with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
study population will include potential participants from primary care and specialty medical referrals, community samples, and self-referral from across the United States.
University of Arizona
Tucson, Arizona, 85724, United States
Lucille Salter Packer Children's Hospital
Stanford, California, 94304, United States
Nemours/Alfred I. duPont Hospital for Children
Wilmington, Delaware, 19803, United States
University of Southern Florida
Tampa, Florida, 33620, United States
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
Harvard Medical School
Boston, Massachusetts, 02115, United States
University of Minnesota
Minneapolis, Minnesota, 55415, United States
Chang K, Frankovich J, Cooperstock M, Cunningham MW, Latimer ME, Murphy TK, Pasternack M, Thienemann M, Williams K, Walter J, Swedo SE; PANS Collaborative Consortium. Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): recommendations from the 2013 PANS Consensus Conference. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):3-13. doi: 10.1089/cap.2014.0084. Epub 2014 Oct 17.
Williams KA, Swedo SE. Post-infectious autoimmune disorders: Sydenham's chorea, PANDAS and beyond. Brain Res. 2015 Aug 18;1617:144-54. doi: 10.1016/j.brainres.2014.09.071. Epub 2014 Oct 7.
Susan E Swedo, M.D.
National Institute of Mental Health (NIMH)
9 participants (actual enrollment reported by the registry).
First Submitted
April 24, 2018
First Posted
April 25, 2018
Study Start
March 20, 2018
Actual (reported)Contact the study team to confirm eligibility.
University of Missouri
Columbia, Missouri, 65205, United States
Primary Completion
October 23, 2019
Actual (reported)Study Completion
October 23, 2019
Actual (reported)Last Updated
October 25, 2019
Record last verified: 2019-10
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Source: ClinicalTrials.gov.
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