Folate One-carbon Malnutrition as the Metabostemness Risk Factor of Malignancy Tumor Development of NSCLC Patients

NCT03504098 | Unknown

• 1 other identifier: 201701123RINC
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Non-small cell lung cancer (NSCLC) accounts for more than two-thirds of lung cancer, which is the leading cause of cancer deaths in Taiwan. The overall prognosis of NSCLC is poor with low 5-year survival rates. Recent advances suggest that malignancy NSCLC cancers are the cancer stem cell (CSC) diseases. The stemness potentials of CSC with epithelial-mesenchymal transdifferentiation ensure their invasion and disseminate to metastsis organs. The self-renewal property of CSC mediates intrinsic drug resistance to cytotoxicity therapy and promoted aggressive relapse tumour. Metabolic reprogramming on bioenergetics of malignant cancer cells has been proposed as the key mediator in the stemness CSC development. Malignancy cells uptake glucose for fermented glycolysis to produce lactate which release resulted in acidified microenvironment to trigger the mTOR and sonic hedgehog metabolic stress signaling in supporting CSC stemness potentials. The metabostemness of cancer cells is the new-dimensional hallmark of malignancy tumour, which may serve as the diagnostic markers for the early detection of malignancy cancers. Folate-mediated one carbon metabolism coordinates glucose into amino acid metabolism to tailor the fuel metabolites in supporting macromolecule synthesis and to sustain the bioenergetics requirement. Acting as the metabolic stressor, low folate intake is associated with increased risks of lung cancers. Folate and one-carbon nutrient status of NSCLC patients in Taiwan, however, has not been assessed. The role of low folate metabolic stress (LFMS) in metabostemness marker and metastasis potentials of malignancy NSCLC is unexplored. The causal effect and the working mechanisms by which LFMS promoted NSCLC malignancy remain elusive.

Conditions

Lung Cancer, Nonsmall Cell

Keywords

One-carbon metabolism; Folate; Choline; metabolomic marker; Cancer risk

Outcome Measures

Primary Outcomes (1)

• Assessment of one-carbon nutrient (folate, choline, betaine, Vitamine B12) intake of lung cancer patients

  Using semiquantitative food frequency questionnaires

  Past 0.5-1 year

Secondary Outcomes (2)

• Measure maternal blood biochemistry (folate, choline, betaine, homocysteine, Vitamine B2, Vitamine B6, Vitamine B12, etc.)

  At baseline

• Assessment of one-carbon nutrient metabolomic markers in lung cancer patient tumor tissue

  3 years

Study Arms (3)

Lung cancer patients tumor

Using to analysis metabolomic markers, one carbon folate nutrition levels in lung cancer patients.

Lung cancer patients blood

Using to analysis folate, B12, homocysteine levels in plasma and RBC. Using to analysis cDNA gene test in buffy coat.

Behavioral: nutrition consult

Lung cancer patients

Supply nutrition counseling

Behavioral: nutrition consult

Interventions

nutrition consult BEHAVIORAL

Post-lung cancer operation diet pattern

Lung cancer patients; Lung cancer patients blood

Eligibility Criteria

• Age: 20 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who was diagnosed as the first time having NSCLC from NTUH. Patients have no chronic disease / other cancer / chemotherapy / radiotherapy. Patients at least 20 years old.

You may qualify if:

• Surgeon diagnosed as the first time having non-small cell lung cancer from the surgical clinic of National Taiwan University Hospital

You may not qualify if:

• Patients Suffer from major diseases such as heart, liver, kidney, or peripheral arterial disease, or having mental illness
• Diabetes and non-lung cancer patients
• Pregnancy, breast-feeding pregnant women

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood sample 10c.c lung tumor tissue non-lung tumor tissue

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell Lung

Condition Hierarchy (Ancestors)

Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Chin-Pao Cheng

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jin-Shing Chen

CONTACT

8862-2312345670918; chenjs@ntu.edu.tw

Rwei-Fen S.Huang

CONTACT

8862-29052512; 034825@mail.fju.edu.tw

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 25, 2018
• First Posted: April 20, 2018
• Study Start: August 1, 2017
• Primary Completion: July 31, 2020
• Study Completion: July 31, 2020
• Last Updated: May 29, 2019

Record last verified: 2019-05

Locations

TW (1)