NCT03497104|Completed
The Markers and Paracetamol Poisoning Study 2
MAPP2
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MAPP2
Sponsor study identifier
observational
464
1 country
1
Study Start
July 1, 2018
Actual (reported)Primary Completion
May 31, 2023
Actual (reported)Study Completion
May 31, 2023
Actual (reported)Paracetamol overdose is one of the most common medical emergencies. Annually in the UK, 100,000 people seek medical attention and 50,000 need hospital admission. Treatment is with the antidote acetylcysteine (NAC), which is effective but takes 21 hours to administer intravenously and frequently produces adverse reactions. Current tools that are used to decide who needs treatment are inadequate. this trial team have identified and validated new blood tests that accurately identify those patients at risk of liver injury by quantifying the fundamental in vivo toxicity mechanisms. This study aim to gain further samples in order to develop a new point-of-care test specifically for the detection of liver damage.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 31, 2023
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 5, 2018
Actual (reported)April 13, 2018
Actual (reported)July 1, 2018
Actual (reported)May 31, 2023
Actual (reported)May 31, 2023
Actual (reported)To establish a biobank of human serum samples from patients with paracetamol overdose to develop and test the performance of our POC Test
3 years
Surplus blood donation
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients presenting to Emergency Department or Acute Medical Unit with paracetamol overdose
NHS Lothian
Edinburgh, United Kingdom
James Dear
University of Edinburgh
464 participants (actual enrollment reported by the registry).
First Submitted
April 5, 2018
First Posted
April 13, 2018
Study Start
July 1, 2018
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
May 31, 2023
Actual (reported)Study Completion
May 31, 2023
Actual (reported)Last Updated
November 15, 2023
Record last verified: 2022-09
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Source: ClinicalTrials.gov.
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