NCT03489811

Brief Summary

This study evaluates the effects of essential oils on anxiety scores among children who have an autism spectrum disorder. One third of the children will receive a control blend of oils, one third of the children will receive a test blend of oils, and the other third will receive a second test blend of oils.

Trial Health

30
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started Jul 2019

Typical duration for not_applicable anxiety

Geographic Reach
1 country

1 active site

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 30, 2018

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 6, 2018

Completed
1.3 years until next milestone

Study Start

First participant enrolled

July 24, 2019

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2021

Completed
Last Updated

November 5, 2021

Status Verified

October 1, 2021

Enrollment Period

2.1 years

First QC Date

March 30, 2018

Last Update Submit

October 29, 2021

Conditions

Keywords

Essential OilsAromatherapyAnxietyAutism Spectrum Disorder

Outcome Measures

Primary Outcomes (1)

  • 39-Question Spence Children's Anxiety Scale (SCAS)

    The Spence Children's Anxiety Scale collects parent-reported signs and symptoms of anxiety at baseline and again at the end of each week of the intervention. Each item is scored as (0) never, (1) sometimes (2) often, or (3)always. The total score ranges from 0-114, with higher scores indicating higher levels of anxiety.

    baseline and day 35

Study Arms (3)

Test Essential Oil Blend

EXPERIMENTAL

Participants in this arm receive the test essential oil inhaler to administer during the 4-week intervention.

Other: Test Essential Oil Blend

Active Essential Oil Blend

ACTIVE COMPARATOR

Participants in this arm receive an active essential oil inhaler to administer during the 4-week intervention.

Other: Active Essential Oil Blend

Control

PLACEBO COMPARATOR

Participants in this arm receive a control inhaler to administer during the 4-week intervention.

Other: Control Blend

Interventions

The test essential oil blend consists of plant derived oils which have been distilled from crude plant matter and analyzed in a laboratory to identify chemical composition.

Test Essential Oil Blend

The active essential oil blend consists of plant derived oils which have been distilled from crude plant matter and analyzed in a laboratory to identify chemical composition.

Active Essential Oil Blend

The control blend consists of inert vegetable oils which are produced from plant matter.

Control

Eligibility Criteria

Age6 Years - 11 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • age: 6-11 years old at enrollment
  • diagnosed with an autism spectrum disorder

You may not qualify if:

  • mast cell activation syndrome
  • history of adverse response to essential oil inhalation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Franklin Institute of Wellness

Franklin, Tennessee, 37067, United States

Location

MeSH Terms

Conditions

Anxiety DisordersAutism Spectrum Disorder

Condition Hierarchy (Ancestors)

Mental DisordersChild Development Disorders, PervasiveNeurodevelopmental Disorders
0

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 30, 2018

First Posted

April 6, 2018

Study Start

July 24, 2019

Primary Completion

August 31, 2021

Study Completion

August 31, 2021

Last Updated

November 5, 2021

Record last verified: 2021-10

Data Sharing

IPD Sharing
Will not share

Data will not be shared.

Locations