Mortality of Sepsis in Swedish Intensive Care Units 2008-2016

NCT03489447 | Completed

• 1 other identifier: 2015/519
• Study Type: observational
• Target: 252,245
• Locations: 0 countries
• Sites: N/A

Brief Summary

A study of short and long term mortality in patients treated with or without a diagnosis of sepsis in Swedish intensive care units (ICU) 2008 - 2016. The cohort is characterized with regard to chronic comorbidity, severity of acute illness and demographic factors, and outcome is adjusted for these factors. Changes in mortality during the period are studied.

Conditions

Sepsis

Outcome Measures

Primary Outcomes (3)

• 30 day mortality

  mortality within 30 days after admission to ICU

  From the day of ICU admission until death of any cause , whichever came first, assessed up to 30 days.

• 90 day mortality

  mortality within 90 days after admission to ICU

  From the day of ICU admission until death of any cause, whichever came first, assessed up to day 90.

• 365 day mortality

  mortality within 365 days after admission to ICU

  From the day of ICU admission until death of any cause , whichever came first, assessed up to day 365.

Secondary Outcomes (3)

• hospital mortality

  From the day of ICU admission until death of any cause or day of hospital discharge, whichever came first, assessed up to day 365.

• ICU length of stay

  From the day of ICU admission until death of any cause or day of ICU discharge, whichever came first, assessed up to day 365.

• hospital length of stay

  From the day of ICU admission until death of any cause or day of hospital discharge , whichever came first, assessed up to day 365.

Study Arms (2)

Sepsis group

All adult (\>= 18 years) patients with a diagnosis of sepsis included in the Swedish ICU Registry between 2008-01-01 and 2016-10-18

Other: ICU care

Non-sepsis group

All adult (\>=18 years) patients without a diagnosis of sepsis included in the Swedish ICU Registry between 2008-01-01 and 2016-10-18

Other: ICU care

Interventions

ICU care OTHER

exposure to ICU treatment with or without diagnosed sepsis

Non-sepsis group; Sepsis group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All adult general ICU patients included in the Swedish Intensive Care Registry 2008-01-01 to 2016-10-18.

You may qualify if:

• Admission to a Swedish general ICU (excluding specialized cardiothoracic, neurosurgical, pediatric and burns units) between 2008-01-01 and 2016-10-18
• Episode registered in Swedish Intensive Care Registry

You may not qualify if:

• Age \< 18 years
• Readmission (only first episode during the period included)

Sponsors & Collaborators

• Uppsala University: lead

Related Publications (1)

• Strandberg G, Walther S, Agvald Ohman C, Lipcsey M. Mortality after Severe Sepsis and Septic Shock in Swedish Intensive Care Units 2008-2016-A nationwide observational study. Acta Anaesthesiol Scand. 2020 Aug;64(7):967-975. doi: 10.1111/aas.13587. Epub 2020 Apr 27.

  PMID: 32232853 DERIVED

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Miklós Lipcsey, PhD

  Uppsala University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 21, 2018
• First Posted: April 5, 2018
• Study Start: January 1, 2008
• Primary Completion: October 25, 2017
• Study Completion: October 25, 2017
• Last Updated: April 5, 2018

Record last verified: 2018-04

Data Sharing

• IPD Sharing: Will not share