Metabolic Dynamics During Physical Activity

NCT03485716 | Completed

• 1 other identifier: Hypoxitrain 2
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to systematically Analyse the metabolome in capillary blood of healthy men and women at rest and during defined standardized physical activity under normobaric normoxia or hypoxia with a specific focus on metabolites and metabolic pattern related to energy metabolism. The metabolome analyses in capillary blood could give us also or more detailed insight into erythrocyte metabolic physiology because it is known for a longer time that the primary metabolism of the erythrocyte reflects its Oxygen Saturation via the glycolytic metabolites / intermediates pattern.

Conditions

Healthy Men and Women

Keywords

metabolism; metabolome; physical activity; hypoxia

Outcome Measures

Primary Outcomes (1)

• Change in capillary lactate/pyruvate Ratio (dimension-free)

  marker for the ratio between anaerobic / aerobic glycolysis

  t = 0 min (before exercise); t = 10, 20 and 30 min during exercise; t = 50 and 60 min during recovery

Study Arms (2)

running under hypoxia - first

EXPERIMENTAL

running under hypoxia (first day) and normoxia (second day)

Other: running on a treadmill under normoxia or hypoxia

running under normoxia - first

ACTIVE COMPARATOR

running under normoxia (first day) and hypoxia (second day)

Other: running on a treadmill under normoxia or hypoxia

Interventions

running on a treadmill under normoxia or hypoxia OTHER

* 30 min running (60% VO2max) on a treadmill under hypoxia (O2: 14%) * 30 min running (60% VO2max) on a treadmill under normoxia (O2: 20%)

running under hypoxia - first; running under normoxia - first

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy volunteers
• written informed consent

You may not qualify if:

• known cardio-vascular, lung, metabolic, endocrine, hematologic, kidney or neurologic diseases
• pregnancy, lactating period
• unability to understand study content and aims and to give written informed consent

Sponsors & Collaborators

• Charite University, Berlin, Germany: lead

Study Sites (1)

Charite University Medicine, ECRC

Berlin, 13125, Germany

Location

MeSH Terms

Conditions

Motor Activity; Hypoxia

Condition Hierarchy (Ancestors)

Behavior; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Michael Boschmann, Dr.

  Charite University, Berlin, Germany

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. Michael Boschmann

Study Record Dates

• First Submitted: March 19, 2018
• First Posted: April 2, 2018
• Study Start: August 1, 2016
• Primary Completion: March 31, 2017
• Study Completion: December 31, 2017
• Last Updated: April 2, 2018

Record last verified: 2018-03

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)