Cortical Dynamics of Inhibitory Control: A Concurrent tDCS-MEG Study

NCT03484377 | Completed

• 2 other identifiers: CiC2017051199-1801
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to use concurrent Transcranial Direct Current Stimulation (tDCS) and Magnetoencephalography (MEG) with measures of impulsivity to examine the neurobiological underpinnings of rapid response impulsivity (RRI) and how these can be modified using tDCS in healthy subjects.

Conditions

Impulsive Behavior

Outcome Measures

Primary Outcomes (1)

• Total number of correct anti-saccade (AS) trials

  A measure of rapid response impulsivity (inhibitory control)

  Change from baseline after 20 minutes of tDCS

Secondary Outcomes (5)

• Total number of correct pro-saccade (PS) trials

  Change from baseline after 20 minutes of tDCS

• Saccade latency for anti-saccade (AS) trials

  Change from baseline after 20 minutes of tDCS

• Saccade latency for pro-saccade (PS) trials

  Change from baseline after 20 minutes of tDCS

• Total Scores on the UPPS+P Impulsive Behaviour Scale

  Baseline

• Alpha and Beta band activity

  Change from baseline after 20 minutes of tDCS

Other Outcomes (1)

• Alpha and Beta band activity

  During 20 minutes of tDCS stimulation

Study Arms (2)

Anodal tDCS

EXPERIMENTAL

The anodal tDCS electrode will be placed over the area corresponding to the right DLPFC (F4 of the EEG10-20 international system). The anodal tDCS condition will use a constant current of 2mA, delivered via gradual increase and decrease over 10 seconds at the onset and offset of stimulation (current ramps), respectively.

Device: Anodal tDCS

Sham tDCS

SHAM COMPARATOR

The sham (cathodal) electrode will be placed over the left supraorbital ridge. The current will be delivered only in the first 10 seconds, after which the stimulation will cease but with the electrodes still in place throughout the session.

Device: Sham tDCS

Interventions

Anodal tDCS DEVICE

The experimental condition will use a constant current of 2mA for 20 minutes, delivered via gradual increase and decrease over 10 seconds at the onset and offset of stimulation (current ramps), respectively.

Anodal tDCS

Sham tDCS DEVICE

The anodal electrode will be placed over the supreorbital ridge. The current will be delivered only in the first 10 seconds, after which the stimulation will cease but with the electrodes still in place throughout the session. The session will last for 20 minutes.

Sham tDCS

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• University students and staff
• Aged 18-40

You may not qualify if:

• Individuals with epilepsy and other neurological conditions, history of significant head injury, substance misuse, major mental disorder and those receiving psychotropic medication.
• Contraindications to use of Magnetic Resonance (pacemakers, metal implants, aneurysm clips)
• Pregnancy.

Sponsors & Collaborators

• Najat Khalifa: lead
• Medical Research Council: collaborator
• University of Nottingham: collaborator

Study Sites (1)

University of Nottingham

Nottingham, Notts, NG7 2TU, United Kingdom

Location

MeSH Terms

Conditions

Impulsive Behavior

Interventions

Transcranial Direct Current Stimulation

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Officials

• Najat Khalifa, DM

  University of Nottingham

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants will be randomly allocated, using a computer generated code, to receive either anodal tDCS or sham. For sham stimulation, the current will be delivered only in the first 10 seconds, after which the stimulation will cease but with the electrodes still in place throughout the session
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor

Model Details: Concurrent tDCS-MEG parallel arms single-blinded experimental design (right anodal v sham tDCS).

Study Record Dates

• First Submitted: March 14, 2018
• First Posted: March 30, 2018
• Study Start: September 15, 2018
• Primary Completion: February 14, 2019
• Study Completion: February 28, 2019
• Last Updated: February 25, 2020

Record last verified: 2020-02

Locations

GB (1)