Crowdsourcing to Promote HBV and HCV Testing in China

NCT03482388 | Completed

• 1 other identifier: 18-0251
• Study Type: interventional
• Target: 700
• Locations: 1 country
• Sites: 1

Brief Summary

This is an online randomized controlled trial (RCT) comparing men who have sex with men (MSM) exposed to a crowdsourced intervention to MSM who did not receive the intervention to determine the effect on Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) testing. Participants will be randomly assigned in a 1:1 ratio to intervention or control using a computer-based allocation system. Participants will be assessed for primary and secondary outcomes four weeks after randomization.

Conditions

Hepatitis; Hepatitis B; Hepatitis C

Keywords

Hepatitis; Hepatitis B; Hepatitis C; Men who have sex with men; Crowdsourcing; China; Testing

Outcome Measures

Primary Outcomes (1)

• Confirmed HBV and HCV test uptake

  Defined as frequency of men who had both HBsAg test uptake and anti-HCV IgG test uptake confirmed through electronic submission of a test report photo showing serology results, age of tester, sex of tester, and date of test

  enrollment - 4 weeks after enrollment

Secondary Outcomes (12)

• Confirmed HBV test uptake

  enrollment - 4 weeks after enrollment

• Confirmed HCV test uptake

  enrollment - 4 weeks after enrollment

• Self-reported HBV test uptake

  enrollment - 4 weeks after enrollment

• Self-reported HCV test uptake

  enrollment - 4 weeks after enrollment

• HBV vaccination uptake

  enrollment - 4 weeks after enrollment

Study Arms (2)

Crowdsourced intervention

EXPERIMENTAL

A multimedia component will deliver two videos and two images promoting HBV and HCV testing developed through a crowdsourcing contest in China. A participatory component will invite men to submit suggestions for how to improve crowdsourced videos and images.

Behavioral: Crowdsourced materials

Control

OTHER

No images or videos will be viewed, and suggestions for improving hepatitis testing materials will not be collected.

Other: Control

Interventions

Crowdsourced materials BEHAVIORAL

Among participants randomized to the intervention arm, intervention images and videos promoting HBV and HCV testing will be delivered through the WeChat platform. Men will also be invited to submit suggestions for how to improve intervention videos and images.

Crowdsourced intervention

Control OTHER

Participants will not view any images or videos promoting HBV and HCV testing.

Control

Eligibility Criteria

• Age: 16 Years+
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• years of age or older
• male
• report having had anal sex with another man at least once in the past
• currently reside in China
• willing to provide working mobile phone number and WeChat account

You may not qualify if:

• previous HBV vaccination
• previous HBV testing
• previous HCV testing

Sponsors & Collaborators

• University of North Carolina, Chapel Hill: lead
• Doris Duke Charitable Foundation: collaborator

Study Sites (1)

UNC Project-China

Guangzhou, China

Location

Related Publications (2)

• Palmer MJ, Henschke N, Villanueva G, Maayan N, Bergman H, Glenton C, Lewin S, Fonhus MS, Tamrat T, Mehl GL, Free C. Targeted client communication via mobile devices for improving sexual and reproductive health. Cochrane Database Syst Rev. 2020 Jul 14;8(8):CD013680. doi: 10.1002/14651858.CD013680.

  PMID: 32779730 DERIVED

• Fitzpatrick T, Zhou K, Cheng Y, Chan PL, Cui F, Tang W, Mollan KR, Guo W, Tucker JD. A crowdsourced intervention to promote hepatitis B and C testing among men who have sex with men in China: study protocol for a nationwide online randomized controlled trial. BMC Infect Dis. 2018 Sep 29;18(1):489. doi: 10.1186/s12879-018-3403-3.

  PMID: 30268114 DERIVED

MeSH Terms

Conditions

Hepatitis; Hepatitis B; Hepatitis C; Homosexuality

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Blood-Borne Infections; Communicable Diseases; Infections; Hepadnaviridae Infections; DNA Virus Infections; Virus Diseases; Hepatitis, Viral, Human; Flaviviridae Infections; RNA Virus Infections; Sexuality; Sexual Behavior; Behavior

Study Officials

• Joseph Tucker, MD, PhD, MA

  University of North Carolina, Chapel Hill

  STUDY DIRECTOR

• Thomas Fitzpatrick

  Institute for Global Health and Infectious Diseases

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants will be randomly assigned in a 1:1 ratio to the study intervention or control

Study Record Dates

• First Submitted: March 22, 2018
• First Posted: March 29, 2018
• Study Start: May 9, 2018
• Primary Completion: May 15, 2018
• Study Completion: June 9, 2018
• Last Updated: June 20, 2018

Record last verified: 2018-06

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: They will be shared upon publication of the main manuscript.

Locations

CN (1)