Anthropogenetic Variability in the Group of Individuals With Febrile Seizures

NCT03481764 | Completed

• 1 other identifier: Sbcprn
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Febrile seizures(FS) are the most common neurological disorder in chilhood and are a great stress for parents due to their dramatic clinical appearance. Using HRC-test(test for determination of homozygously recessive characteristics in humans) we analyzed presence, distribution, and individual combination of 20 selected genetically controlled morpho-physiological traits among FS patients and control to determine a possible deviation in the homozygosity level and genetic loads in the group of affected children and whether there is a predisposition to the occurrence of FS.

Conditions

Febrile Seizure

Keywords

febrile seizure; HRC-test; genetic variation; epilepsy

Outcome Measures

Primary Outcomes (1)

• To establish the degree of genetic homozygosity and variability in subjects with Febrile Seizure and control group

  Using HRC-test (test for determination of homozygously recessive characteristics in humans) we will analyzed presence, distribution, and individual combination of 20 selected genetically controlled morpho-physiological traits among FS patients and control to determine a possible deviation in the homozygosity level and genetic loads in the group of affected children and whether there is a predisposition to the occurrence of FS.

  2 years

Secondary Outcomes (1)

• Establish a correlation between the degree of genetic homozygosity and variability between subjects with SFS and CFS, also WFS and EFS

  2 years

Study Arms (6)

FS: Febrile Seizures

Involved patient with diagnosed Febrile Seizures which were hospitalized or recieved ambulatory treatment in University Children´s Hospital in Belgrade. Ages 5-14 years

Genetic: HRC-test

CN: Control group

The control group was made of healthy children older than 5 years of age, which have never had any neurological disorders in their anamnesis and who were patients in preschool or school dispensaries in the city of Belgrade

Genetic: HRC-test

SFS : group of individuals with simple FS

Simplex febrile seizures (SFS) last shorter than 15 minutes and their type is tonic-clonic. Also, they did not show signs of recidivism during the first 24 hours and were diagnosed at the patients aged from 6th months to 5th year

Genetic: HRC-test

CFS : group of individuals with complex FS

Complex febrile seizures (CFS) were diagnosed at those patients that had focal seizure or epileptic status or seizure having the body temperature lower than 38 degree, which occurred outside of the typical age group and finally which repeated in the first 24 hours again

Genetic: HRC-test

WFS: group of individuals with FS and without epilepsia

group of children with Febrile Seizure and not developed epilepsia

Genetic: HRC-test

EFS: group of individuals with epilepsia and Febrile Seizures

Group of children with Febrile Seizures, who have developed Epilepsy

Genetic: HRC-test

Interventions

HRC-test GENETIC

Using HRC-test we analyze 20 selected genetically controlled morphophysiological traits among FS children and control.Homozygous-recessive traits in the region of human head are: attached ear lobe,continuous frontal hair line,blue eyes straight hair,soft hair and blond hair,double hair whorl,hair whorl orientation-opposite from clock-wise,as well as an inability to roll,fold and curve the tongue,a guttural "r and Daltonism.HRC trait expressed in human arms and legs, such as distal or proximal hyper-extensibility of the thumb,index finger shorter than the ring finger,left-handedness, hand clasping pattern.In order to achieve high level of objectivity during the process of data gathering, the same person conducting all testing.Inside the group of charcteristics which show high level of variability,only the extreme phenotypes were considered recessive.For the purpose of testing the color blindness in examinees,the Pseudoisochromatic plates test was used.

CFS : group of individuals with complex FS; CN: Control group; EFS: group of individuals with epilepsia and Febrile Seizures; FS: Febrile Seizures; SFS : group of individuals with simple FS; WFS: group of individuals with FS and without epilepsia

Eligibility Criteria

• Age: 5 Years - 14 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

The Febrile Seizure affected children as well as the individuals from the control group were members of the same population (Serbian)

You may qualify if:

• Our research has involved patient with diagnosed Febrile Seizure which were hospitalized or recieved ambulatory treatment in University Children´s Hospital in Belgrade.

You may not qualify if:

• Patients with evidence of intracranial infections
• Patients with incomplited medical documentation

Sponsors & Collaborators

• Institut za Rehabilitaciju Sokobanjska Beograd: lead

Study Sites (1)

Sanja Dimitrijevic

Belgrade, 11000, Serbia

Location

Related Publications (6)

• Nikolic D, Petronic I, Cvjeticanin S, Brdar R, Cirovic D, Bizic M, Konstantinovic L, Matanovic D. Gender and morphogenetic variability of patients with spina bifida occulta and spina bifida aperta: prospective population-genetic study. Hippokratia. 2012 Jan;16(1):35-9.

  PMID: 23930055 BACKGROUND

• Cvjeticanin S, Marinkovic D. Morphogenetic variability during selection of elite water polo players. J Sports Sci. 2009 Jul;27(9):941-7. doi: 10.1080/02640410902960494.

  PMID: 19629843 BACKGROUND

• Marinkovic D, Cvjeticanin S. Population-genetic study of Balkan endemic nephropathy in Serbia. Genetika. 2007 Aug;43(8):1134-8.

  PMID: 17958315 BACKGROUND

• Cvjeticanin S, Marinkovic D. Genetic variability in the group of patients with congenital hip dislocation. Genetika. 2005 Aug;41(8):1142-6.

  PMID: 16161637 BACKGROUND

• Khair AM, Elmagrabi D. Febrile Seizures and Febrile Seizure Syndromes: An Updated Overview of Old and Current Knowledge. Neurol Res Int. 2015;2015:849341. doi: 10.1155/2015/849341. Epub 2015 Nov 30.

  PMID: 26697219 BACKGROUND

• Dimitrijevic S, Cvjeticanin S, Pusica A, Jekic B, Filipovic T, Nikolic D. Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study. Biomed Res Int. 2018 Jul 5;2018:7845904. doi: 10.1155/2018/7845904. eCollection 2018.

  PMID: 30069480 BACKGROUND

MeSH Terms

Conditions

Seizures, Febrile; Epilepsy

Condition Hierarchy (Ancestors)

Seizures; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Brain Diseases; Central Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 22, 2018
• First Posted: March 29, 2018
• Study Start: September 1, 2015
• Primary Completion: April 1, 2018
• Study Completion: September 1, 2019
• Last Updated: April 28, 2020

Record last verified: 2020-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR

Locations

SE (1)