The Genetics of Pulmonary Fibrosis

NCT03478553 | Recruiting

• 2 other identifiers: 15-1147W81XWH-17-1-0597_1a
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study seeks to screen first degree family members of people with Idiopathic Pulmonary Fibrosis (IPF) for the earliest signs of lung fibrosis.

Conditions

Idiopathic Pulmonary Fibrosis (IPF)

Outcome Measures

Primary Outcomes (1)

• Identify and explore genetic loci and related environmental exposures in individuals with familial pulmonary fibrosis and their relatives.

  The investigators aim is to identify and explore genetic loci that affect development of pulmonary fibrosis and also explore related environmental exposures. Idiopathic pulmonary fibrosis (IPF) is one of the interstitial lung diseases under the broader umbrella of idiopathic interstitial pneumonias (IIP). The investigators hypothesize that inherited genetic factors are associated with pulmonary fibrosis.

  Baseline

Study Arms (2)

People with IPF

Other: Blood draw; Other: Questionnaire

Family members without IPF

Other: Blood draw; Other: Questionnaire

Interventions

Blood draw OTHER

Blood draw

Family members without IPF; People with IPF

Questionnaire OTHER

Pulmonary Fibrosis Questionnaire

Family members without IPF; People with IPF

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Study population will include up to 20,000 people in the country, both people with IPF and their family members who have never been diagnosed with IPF.

You may qualify if:

• Age at least 18 years old
• Family member diagnosed with IPF

You may not qualify if:

• \- No family member with IPF

Sponsors & Collaborators

• University of Colorado, Denver: lead

Study Sites (1)

University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples including DNA, RNA, Plasma

MeSH Terms

Conditions

Idiopathic Pulmonary Fibrosis

Interventions

Blood Specimen Collection; Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Pulmonary Fibrosis; Lung Diseases, Interstitial; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques; Data Collection; Epidemiologic Methods; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• David A Schwartz, MD

  University of Colorado, Denver

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Rachel Warren

CONTACT

303-724-8569; rachel.warren@cuanschutz.edu

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 12, 2018
• First Posted: March 27, 2018
• Study Start: January 18, 2018
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: March 25, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)